Mass Spectrometry Imaging: Applications in Drug Distribution Studies
文献类型：期刊论文
| 作者 | Zhao, Yuan-Sheng3; Li, Chuan1,2,4 |
| 刊名 | CURRENT DRUG METABOLISM
 |
| 出版日期 | 2015 |
| 卷号 | 16期号:9页码:807-815 |
| 关键词 | Drug distribution MALDI Mass spectrometry imaging metabolites |
| ISSN号 | 1389-2002 |
| DOI | 10.2174/1389200216666150812124459 |
| 文献子类 | Article |
| 英文摘要 | In the past decade, mass spectrometry imaging (MSI) has received an increasing amount of attention due to its ability in displaying the spatial distribution of a wide range of molecules, including peptides, proteins, lipids, endogenous and exogenous metabolites, and xenobiotics in biological tissues. Information regarding drug localization within tissues provides a better understanding of pharmacokinetic behaviors and pharmacological and toxicological effects. This review presents an introduction to MSI, along with an in-depth analysis of its general process. In addition, we highlighted several examples of various intensive applications of imaging drugs and metabolites in tissues by mass spectrometry. Furthermore, we present the prospect of quantitative MSI of small molecular chemicals, which may be particularly attractive to researchers in the pharmaceutical industry today. It is expected that with technological advancement, MSI will become an increasingly powerful tool in drug disposition studies and other fields of biomedical research. |
| WOS关键词 | DESORPTION ELECTROSPRAY-IONIZATION ; RAT-BRAIN TISSUE ; MATRIX APPLICATION METHOD ; ATMOSPHERIC-PRESSURE ; SAMPLE PREPARATION ; BIOLOGICAL TISSUE ; MALDI-MS ; MOLECULAR ANALYSIS ; AMBIENT CONDITIONS ; INTERNAL STANDARD |
| WOS研究方向 | Biochemistry & Molecular Biology ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000365624600007 |
| 出版者 | BENTHAM SCIENCE PUBL LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276685]  |
| 专题 | 上海药物代谢研究中心 科研与新药推进处 |
| 通讯作者 | Zhao, Yuan-Sheng |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China; 2.China Acad Chinese Med Sci, Inst Chinese Mat Med, Beijing, Peoples R China 3.Mt Sinai Sch Med, Dept Pharmacol & Syst Therapeut, New York, NY 10029 USA; 4.Chinese Acad Sci, Grad Sch, Shanghai, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Zhao, Yuan-Sheng,Li, Chuan. Mass Spectrometry Imaging: Applications in Drug Distribution Studies[J]. CURRENT DRUG METABOLISM,2015,16(9):807-815. |
| APA | Zhao, Yuan-Sheng,&Li, Chuan.(2015).Mass Spectrometry Imaging: Applications in Drug Distribution Studies.CURRENT DRUG METABOLISM,16(9),807-815. |
| MLA | Zhao, Yuan-Sheng,et al."Mass Spectrometry Imaging: Applications in Drug Distribution Studies".CURRENT DRUG METABOLISM 16.9(2015):807-815. |
入库方式： OAI收割
来源：上海药物研究所
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