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Association between Common CYP1A2 Polymorphisms and Theophylline Metabolism in Non-smoking Healthy Volunteers

文献类型：期刊论文

作者Wang, Liqing2; Hu, Zheyi1; Deng, Xun2; Wang, Yong2; Zhang, Zhongyi2; Cheng, Ze-Neng3
刊名BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
出版日期2013-04
卷号112期号:4页码:257-263
ISSN号1742-7835
DOI10.1111/bcpt.12038
文献子类Article
英文摘要This study was designed to investigate the impact of cytochrome P450 (CYP) 1A2 polymorphisms on theophylline metabolism in a non-smoking healthy male Chinese population. Four polymorphisms CYP1A2*1C (G-3860A), G-3113A, CYP1A2*1F (C-163A) and CYP1A2*1B (C-5347T) were screened in 238 unrelated male volunteers. Then, a single oral 200-mg dose of theophylline was administered to 37 volunteers, who were selected from 238 volunteers based on the CYP1A2 genotype. CYP1A2 activities were evaluated by plasma 1,7-dimethylxanthine/caffeine ratios (17X/137X) after administration of 100-mg caffeine. The plasma concentrations of theophylline, 17X and 137X were determined by high-performance liquid chromatography. The activity of CYP1A2 was lower in volunteers with the -3113 AA genotype compared with those with the -3113 AG genotype (0.35 +/- 0.04 versus 0.48 +/- 0.07, p=0.016) or the -3113 GG genotype (0.35 +/- 0.04 versus 0.58 +/- 0.22, p=0.037). CYP1A2*1F polymorphisms were associated with increased CYP1A2 activity in volunteers with -3860G/-3113G/5347C homozygosity (0.66 +/- 0.24 versus 0.46 +/- 0.05, p=0.034). However, theophylline metabolism showed no difference among volunteers carrying different haplotype pairs. CYP1A2 genetic polymorphisms influenced CYP1A2 enzyme activity as measured by caffeine, but CYP1A2 gene polymorphisms appeared to have limited influence on theophylline metabolism in our study.
WOS关键词SINGLE-NUCLEOTIDE POLYMORPHISMS ; GENETIC-POLYMORPHISM ; HUMAN LIVER ; ORAL THEOPHYLLINE ; CAFFEINE ; CYTOCHROME-P450 ; ASTHMA ; INDUCIBILITY ; PLASMA ; COFFEE
资助项目Medical Scientific Research Foundation of Guangdong Province, China[2009B162]
WOS研究方向Pharmacology & Pharmacy ; Toxicology
语种英语
WOS记录号WOS:000316217100007
出版者WILEY-BLACKWELL
源URL[http://119.78.100.183/handle/2S10ELR8/277679]  
专题上海药物代谢研究中心
通讯作者Zhang, Zhongyi
作者单位1.Chinese Acad Sci, Shanghai Ctr DMPK Res, Shanghai Inst Mat, Shanghai, Peoples R China;
2.Southern Med Univ, Zhujiang Hosp, Dept Pharm, Guangzhou 510282, Guangdong, Peoples R China;
3.Cent S Univ, Sch Pharmaceut Sci, Res Inst Drug Metab & Pharmacokinet, Med & Grad Sch, Changsha 410013, Hunan, Peoples R China
推荐引用方式
GB/T 7714		 Wang, Liqing,Hu, Zheyi,Deng, Xun,et al. Association between Common CYP1A2 Polymorphisms and Theophylline Metabolism in Non-smoking Healthy Volunteers[J]. BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY,2013,112(4):257-263.
APA Wang, Liqing,Hu, Zheyi,Deng, Xun,Wang, Yong,Zhang, Zhongyi,&Cheng, Ze-Neng.(2013).Association between Common CYP1A2 Polymorphisms and Theophylline Metabolism in Non-smoking Healthy Volunteers.BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY,112(4),257-263.
MLA Wang, Liqing,et al."Association between Common CYP1A2 Polymorphisms and Theophylline Metabolism in Non-smoking Healthy Volunteers".BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY 112.4(2013):257-263.

入库方式： OAI收割

来源：上海药物研究所

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