Strategies for Improving the Quantitative Bioanalytical Performance of LC-MS in Pharmacokinetic Studies
文献类型：期刊论文
| 作者 | Li, Li3; Tian, Dandan1; Chen, Feng1,2; Yang, Junling ; Yu, Ke; Sun, Yan
|
| 刊名 | CURRENT DRUG METABOLISM
 |
| 出版日期 | 2012-11 |
| 卷号 | 13期号:9页码:1206-1212 |
| 关键词 | Pharmacokinetics LC-MS matrix effects sensitivity enhancement LC-electrolyte effects pulse gradient chromatography |
| ISSN号 | 1389-2002 |
| DOI | 10.2174/138920012803341320 |
| 文献子类 | Review |
| 英文摘要 | Quantitative bioanalysis is urgently required for the evaluation of pharmacokinetic properties of a drug and to demonstrate the body exposure to the parent drug and/or metabolite for interpretation of the efficacy and toxicity. New trends in drug discovery and development will be always posing challenges on LC-MS-based quantitative bioanalysis. The focus of this minireview is to highlight the commonly used strategies for improving the quantitative bioanalytical performance including overcoming matrix effects and improving MS detectability. "LC-electrolyte effects" and "pulse gradient chromatography" proposed by our group are new approaches that have also showed potential efficiencies on improving overall bioassay performance, including lowering lower limit of quantification (LLOQ), enlarging upper limit of quantification (ULOQ), decreasing matrix effects, and overcoming elutropic effects, etc.. They should also work well in metabolic profiling studies and other important analytical fields, such as food pesticide residue analysis, environmental analysis, clinical and forensic toxicology, doping control, and so on. |
| WOS关键词 | TANDEM MASS-SPECTROMETRY ; LIQUID-CHROMATOGRAPHY ; ELECTROSPRAY-IONIZATION ; SIGNAL SUPPRESSION ; (5R)-5-HYDROXYTRIPTOLIDE LLDT-8 ; DRUG-METABOLISM ; CHEMICAL DERIVATIZATION ; ION SUPPRESSION ; DYNAMIC-RANGE ; HUMAN PLASMA |
| 资助项目 | National Natural Science Foundation of China[81102878] ; National Natural Science and Technology Major Project of China "Key New Drug Creation and Manufacturing Program"[2009ZX09304-002] ; National Basic Research Program of China[2012CB518403] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000309510200002 |
| 出版者 | BENTHAM SCIENCE PUBL LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277894]  |
| 专题 | 上海药物代谢研究中心 |
| 通讯作者 | Li, Li |
| 作者单位 | 1.Chinese Acad Sci, Grad Sch, Shanghai 201203, Peoples R China; 2.Hainan Med Coll, Sch Pharm, Haikou, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Lab DMPK Res Herbal Med, Shanghai 201203, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Li, Li,Tian, Dandan,Chen, Feng,et al. Strategies for Improving the Quantitative Bioanalytical Performance of LC-MS in Pharmacokinetic Studies[J]. CURRENT DRUG METABOLISM,2012,13(9):1206-1212. |
| APA | Li, Li,Tian, Dandan,Chen, Feng,Yang, Junling,Yu, Ke,&Sun, Yan.(2012).Strategies for Improving the Quantitative Bioanalytical Performance of LC-MS in Pharmacokinetic Studies.CURRENT DRUG METABOLISM,13(9),1206-1212. |
| MLA | Li, Li,et al."Strategies for Improving the Quantitative Bioanalytical Performance of LC-MS in Pharmacokinetic Studies".CURRENT DRUG METABOLISM 13.9(2012):1206-1212. |
入库方式： OAI收割
来源：上海药物研究所
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