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Distribution of CYP2C9*13 allele in the Chinese Han and the long-range haplotype containing CYP2C9*13 and CYP2C19*2

文献类型：期刊论文

作者Si, Dayong2,3; Wang, Juan3; Zhang, Yifan1; Zhong, Dafang1; Zhou, Hui2,3
刊名BIOPHARMACEUTICS & DRUG DISPOSITION
出版日期2012-09
卷号33期号:6页码:342-345
关键词CYP2C9*13 CYP2C19*2 haplotype long-range
ISSN号0142-2782
DOI10.1002/bdd.1804
文献子类Article
英文摘要Cytochrome P450 2C9 (CYP2C9) and CYP2C19, located in tandem on chromosome 10q2324, are known as genetically polymorphic. CYP2C9*13 is an important CYP2C9 variant in Asian populations, and is correlated with the reduced plasma clearance of some clinically important drugs. In this research, the allele frequency of CYP2C9*13 was determined to be 0.42% (95% CI of 0.17% to 0.86%) in 839 Chinese Han, male subjects. All detected subjects with CYP2C9*13 carry the CYP2C19*2 allele, too. Sequencing results infer the CYP2C9*13 haplotype, which contains eight linked SNPs, originates from the CYP2C9*1B haplotype group. CYP2C9*1B has been reported to be linked with CYP2C19*2. These indicate a long-range haplotype containing the CYP2C9*13 and CYP2C19*2 mutation, which means most CYP2C9*13 carriers will carry the CYP2C19*2 allele and the six SNPs of the CYP2C9*1B haplotype group, and may have more reduced intrinsic clearance of drugs such as phenytoin, tolbutamide and chlorpropamide that are metabolized by both CYP2C9 and CYP2C19. Copyright (c) 2012 John Wiley & Sons, Ltd.
WOS关键词GENETIC POLYMORPHISMS ; CYP2C9 ALLELES ; PHARMACOKINETICS ; METABOLISM ; VARIANTS ; LOSARTAN ; JAPANESE ; IDENTIFICATION ; POPULATIONS ; FREQUENCIES
资助项目Natural Science Foundation of China[30772621] ; Natural Science Foundation of China[81102508] ; Fundamental Research Funds for the Central Universities[201103185]
WOS研究方向Pharmacology & Pharmacy
语种英语
WOS记录号WOS:000308639300007
出版者WILEY-BLACKWELL
源URL[http://119.78.100.183/handle/2S10ELR8/277957]  
专题上海药物代谢研究中心
通讯作者Zhou, Hui
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China
2.Jilin Univ, Key Lab Evolut Past Life & Environm NE Asia, Minist Educ, Changchun 130023, Peoples R China;
3.Jilin Univ, Coll Life Sci, Changchun 130023, Peoples R China;
推荐引用方式
GB/T 7714		 Si, Dayong,Wang, Juan,Zhang, Yifan,et al. Distribution of CYP2C9*13 allele in the Chinese Han and the long-range haplotype containing CYP2C9*13 and CYP2C19*2[J]. BIOPHARMACEUTICS & DRUG DISPOSITION,2012,33(6):342-345.
APA Si, Dayong,Wang, Juan,Zhang, Yifan,Zhong, Dafang,&Zhou, Hui.(2012).Distribution of CYP2C9*13 allele in the Chinese Han and the long-range haplotype containing CYP2C9*13 and CYP2C19*2.BIOPHARMACEUTICS & DRUG DISPOSITION,33(6),342-345.
MLA Si, Dayong,et al."Distribution of CYP2C9*13 allele in the Chinese Han and the long-range haplotype containing CYP2C9*13 and CYP2C19*2".BIOPHARMACEUTICS & DRUG DISPOSITION 33.6(2012):342-345.

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来源：上海药物研究所

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