PLGA-PEG-PLGA hydrogel for ocular drug delivery of dexamethasone acetate
文献类型：期刊论文
| 作者 | Gao, Yuan2; Sun, Yan1; Ren, Fuzheng3; Gao, Shen2 |
| 刊名 | DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
 |
| 出版日期 | 2010-10 |
| 卷号 | 36期号:10页码:1131-1138 |
| 关键词 | Dexamethasone in situ gelling ocular drug delivery PLGA-PEG-PLGA thermosensitive copolymer |
| ISSN号 | 0363-9045 |
| DOI | 10.3109/03639041003680826 |
| 文献子类 | Article |
| 英文摘要 | Aim: This study aims to investigate the suitability of thermosensitive triblock polymer poly-(DL-lactic acid-co- glycolic acid) (PLGA)-polyethylene glycol (PEG)-PLGA as a matrix material for ocular delivery of dexamethasone acetate (DXA). Methods: The copolymer was synthesized and evaluated for its thermosensitive and gelation properties. DXA in situ gel-forming solution based on PLGA-PEG-PLGA copolymer of 20% (w/w) was prepared and evaluated for ocular pharmacokinetics in rabbit according to the microdialysis method, which was compared to the normal eye drop. Result: The copolymer with 20% (w/w) had a low critical solution temperature of 32 degrees C, which is close to the surface temperature of the eye. The C-max of DXA in the anterior chamber for the PLGA-PEG-PLGA solution was 125.2 mu g/mL, which is sevenfold higher than that of the eye drop, along with greater area under the concentration-time curves (AUC). Conclusion: These results suggest that the PLGA-PEG-PLGA copolymer is potential thermosensitive in situ gel-forming material for ocular drug delivery, and it may improve the bioavailability, efficacy of some eye drugs. |
| WOS关键词 | BIODEGRADABLE BLOCK-COPOLYMERS ; TRIBLOCK COPOLYMERS ; THERMOREVERSIBLE GELATION ; FORMING HYDROGELS ; MICRODIALYSIS ; PHARMACOKINETICS ; SYSTEMS |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000282523500001 |
| 出版者 | INFORMA HEALTHCARE |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278760]  |
| 专题 | 上海药物代谢研究中心 |
| 通讯作者 | Gao, Shen |
| 作者单位 | 1.Shanghai Inst Mat Med, Shanghai, Peoples R China; 2.Second Mil Med Univ, Changhai Hosp, Shanghai 200433, Peoples R China; 3.E China Univ Sci & Technol, Shanghai 200237, Peoples R China |
| 推荐引用方式 GB/T 7714 | Gao, Yuan,Sun, Yan,Ren, Fuzheng,et al. PLGA-PEG-PLGA hydrogel for ocular drug delivery of dexamethasone acetate[J]. DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY,2010,36(10):1131-1138. |
| APA | Gao, Yuan,Sun, Yan,Ren, Fuzheng,&Gao, Shen.(2010).PLGA-PEG-PLGA hydrogel for ocular drug delivery of dexamethasone acetate.DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY,36(10),1131-1138. |
| MLA | Gao, Yuan,et al."PLGA-PEG-PLGA hydrogel for ocular drug delivery of dexamethasone acetate".DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY 36.10(2010):1131-1138. |
入库方式： OAI收割
来源：上海药物研究所
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