Preparation and Enhanced Oral Bioavailability of Cryptotanshinone-Loaded Solid Lipid Nanoparticles
文献类型：期刊论文
| 作者 | Hu, LianDong2; Xing, Qianbin2; Meng, Jian1 ; Shang, Chuang2
|
| 刊名 | AAPS PHARMSCITECH
 |
| 出版日期 | 2010-06 |
| 卷号 | 11期号:2页码:582-587 |
| 关键词 | absorption bioavailability cryptotanshinone high-pressure homogenization solid lipid nanoparticles |
| ISSN号 | 1530-9932 |
| DOI | 10.1208/s12249-010-9410-3 |
| 文献子类 | Article |
| 英文摘要 | In this study, solid lipid nanoparticles (SLNs) were successfully prepared by an ultrasonic and high-pressure homogenization method to improve the oral bioavailability of the poorly water-soluble drug cryptotanshinone (CTS). The particle size and distribution, drug loading capacity, drug entrapment efficiency, zeta potential, and long-term physical stability of the SLNs were characterized in detail. A pharmacokinetic study was conducted in rats after oral administration of CTS in different SLNs, and it was found that the relative bioavailability of CTS in the SLNs was significantly increased compared with that of a CTS-suspension. The incorporation of CTS in SLNs also markedly changes the metabolism behavior of CTS to tanshinone IIA. These results indicate that CTS absorption is enhanced significantly by employing SLN formulations, and SLNs represent a powerful approach for improving the oral absorption of poorly soluble drugs. |
| WOS关键词 | DRUG-DELIVERY SYSTEMS ; SALVIA-MILTIORRHIZA ; MASS-SPECTROMETRY ; TANSHINONE-IIA ; IN-VITRO ; ABSORPTION ; METABOLITE ; PLASMA ; CELLS ; SLN |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000278921400012 |
| 出版者 | SPRINGER |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278877]  |
| 专题 | 上海药物代谢研究中心 |
| 通讯作者 | Hu, LianDong |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 2.Hebei Univ, Sch Pharm, Baoding 071002, Hebei Province, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Hu, LianDong,Xing, Qianbin,Meng, Jian,et al. Preparation and Enhanced Oral Bioavailability of Cryptotanshinone-Loaded Solid Lipid Nanoparticles[J]. AAPS PHARMSCITECH,2010,11(2):582-587. |
| APA | Hu, LianDong,Xing, Qianbin,Meng, Jian,&Shang, Chuang.(2010).Preparation and Enhanced Oral Bioavailability of Cryptotanshinone-Loaded Solid Lipid Nanoparticles.AAPS PHARMSCITECH,11(2),582-587. |
| MLA | Hu, LianDong,et al."Preparation and Enhanced Oral Bioavailability of Cryptotanshinone-Loaded Solid Lipid Nanoparticles".AAPS PHARMSCITECH 11.2(2010):582-587. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。