Pharmacokinetic studies of meloxicam following oral and transdermal administration in Beagle dogs
文献类型：期刊论文
| 作者 | Yuan, Yue1; Chen, Xiao-yan2 ; Li, San-ming1; Wei, Xiu-yan1; Yao, Hui-min1; Zhong, Da-fang2
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| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 2009-07 |
| 卷号 | 30期号:7页码:1060-1064 |
| 关键词 | meloxicam pharmacokinetics synovial fluid cutaneous administration liquid chromatography-tandem mass spectrometry |
| ISSN号 | 1671-4083 |
| DOI | 10.1038/aps.2009.73 |
| 文献子类 | Article |
| 英文摘要 | Aim: The potential for topical delivery of meloxicam was investigated by examining its pharmacokinetic profiles in plasma and synovial fluid following oral and transdermal administration in Beagle dogs. Methods: The experiment was a two-period, crossover design using 6 Beagle dogs. Meloxicam tablets were administered orally at a dose of 0.31 mg/kg, and meloxicam gel was administered transdermally at a dose of 1.25 mg/kg. Drug concentrations in plasma and synovial fluid were determined by liquid chromatography-tandem mass spectrometry (LC/MS/MS). The pharmacokinetic parameters were calculated using the Topfit 2.0 program. Results: The pharmacokinetic results showed that AUC(0-t) (23.9 +/- 8.26 mu g.h.mL(-1)) in plasma after oral administration was significantly higher than after transdermal delivery (1.00 +/- 0.43 mu g.h.mL(-1)). In contrast, the ratio of the average concentration in synovial fluid to that in plasma following transdermal administration was higher than that for an oral delivery. The synovial fluid concentration in the treated leg was much higher than that in the untreated leg, whereas the synovial fluid concentration in the untreated leg was similar to the plasma concentration. Conclusion: The high concentration ratio of synovial fluid to plasma indicates direct penetration of meloxicam following topical administration to the target tissue. This finding is further supported by the differences observed in meloxicam concentrations in synovial fluid in the treated and untreated joints at the same time point. Our results suggest that transdermal delivery of meloxicam is a promising method for decreasing its adverse systemic effects. |
| WOS关键词 | LOCAL TISSUE DISPOSITION ; TOPICAL APPLICATION ; DICLOFENAC ; DRUGS |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| CSCD记录号 | CSCD:3628684 |
| WOS记录号 | WOS:000268066400025 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279192]  |
| 专题 | 上海药物代谢研究中心 |
| 通讯作者 | Zhong, Da-fang |
| 作者单位 | 1.Shenyang Pharmaceut Univ, Shenyang 110016, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Yuan, Yue,Chen, Xiao-yan,Li, San-ming,et al. Pharmacokinetic studies of meloxicam following oral and transdermal administration in Beagle dogs[J]. ACTA PHARMACOLOGICA SINICA,2009,30(7):1060-1064. |
| APA | Yuan, Yue,Chen, Xiao-yan,Li, San-ming,Wei, Xiu-yan,Yao, Hui-min,&Zhong, Da-fang.(2009).Pharmacokinetic studies of meloxicam following oral and transdermal administration in Beagle dogs.ACTA PHARMACOLOGICA SINICA,30(7),1060-1064. |
| MLA | Yuan, Yue,et al."Pharmacokinetic studies of meloxicam following oral and transdermal administration in Beagle dogs".ACTA PHARMACOLOGICA SINICA 30.7(2009):1060-1064. |
入库方式： OAI收割
来源：上海药物研究所
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