Advances in particle shape engineering for improved drug delivery
文献类型：期刊论文
| 作者 | Yang, Yiwei1,3; Nie, Di1,3; Liu, Yuan3; Yu, Miaorong1,3; Gan, Yong2,3
|
| 刊名 | Drug discovery today
 |
| 出版日期 | 2018-10-17 |
| ISSN号 | 1878-5832 |
| DOI | 10.1016/j.drudis.2018.10.006 |
| 文献子类 | Article;Review |
| 英文摘要 | Spherical particles such as liposomes and microspheres are the most common and extensively applied drug vehicles. However, researchers have come to realize the superiority of nonspherical nanoparticles. Actually, in human bodies red blood cells, gut biotics and many well-known pathogens have distinct shapes. It can be reasonably inferred that particle shape plays a pivotal part in human bodies. In this review, we summarize the recent studies about the effect of shape on delivery processes such as cellular uptake, tissue penetration and biodistribution. The underlying mechanisms that are relevant to the phenomena revealed, owing to experimental and computational modern techniques, will be addressed, and we shall provide future perspectives on particle design to improve the efficacy of drug delivery. |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/266327]  |
| 专题 | 药物制剂研究中心 |
| 通讯作者 | Gan, Yong |
| 作者单位 | 1.University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing 100049, China; 2.University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing 100049, China 3.Shanghai Institute of Materia Medica, Chinese Academy of Sciences, No. 501 Haike Road, Shanghai 201203, China; |
| 推荐引用方式 GB/T 7714 | Yang, Yiwei,Nie, Di,Liu, Yuan,et al. Advances in particle shape engineering for improved drug delivery[J]. Drug discovery today,2018. |
| APA | Yang, Yiwei,Nie, Di,Liu, Yuan,Yu, Miaorong,&Gan, Yong.(2018).Advances in particle shape engineering for improved drug delivery.Drug discovery today. |
| MLA | Yang, Yiwei,et al."Advances in particle shape engineering for improved drug delivery".Drug discovery today (2018). |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。