A "Ship-in-a-Bottle" strategy to create folic acid nanoclusters inside the nanocages of γ-cyclodextrin metal-organic frameworks
文献类型：期刊论文
| 作者 | Xu, Jian2,3; Wu, Li2,4; Guo, Tao2; Zhang, Guoqing1,2; Wang, Caifen2; Li, Haiyan2 ; Li, Xue5; Singh, Vikramjeet2,5; Chen, Weidong1; Gref, Ruxandra5
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| 刊名 | International journal of pharmaceutics
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| 出版日期 | 2018-12-08 |
| 卷号 | 556页码:89-96 |
| ISSN号 | 1873-3476 |
| DOI | 10.1016/j.ijpharm.2018.11.074 |
| 文献子类 | Article |
| 英文摘要 | Assembled between γ-cyclodextrins (CD) and potassium ions, γ-cyclodextrin metal-organic frameworks (CD-MOF) create spatially extended and ordered cage-like structures. Herein, it was demonstrated that folic acid (FA), a model molecule, could be densely packed inside CD-MOF reaching 2:1 FA:CD molar ratio. This "Ship-in-a-Bottle" strategy leads to a 1450 fold increase of the apparent solubility of FA. Moreover, the bioavailability of FA inside CD-MOF in rats was enhanced by a factor of 1.48 as compared to free FA. The unique mechanism of FA incorporation in the CD-MOF 3D network was also explored, which was different from the conventional CD inclusion complexation. Taylor dispersion investigations indicated that FA was incorporated on the basis of a two-component model, which was further supported by a set of complementary methods, including SEM, XRPD, BET, SR-FTIR, SAXS and molecular simulation. The hypothesized mechanism suggested that: i) tiny FA nanoclusters formed inside the hydrophilic cavities and onto the surface of CD-MOF and ii) FA was included inside dual-CD units in CD-MOF. In a nutshell, this dual incorporation mechanism is an original approach to dramatically increase the drug apparent solubility and bioavailability, and could be a promising strategy for other poorly soluble drugs. |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/266334]  |
| 专题 | 药物制剂研究中心 |
| 通讯作者 | Chen, Weidong; Gref, Ruxandra; Zhang, Jiwen |
| 作者单位 | 1.School of Pharmaceutical Sciences, Anhui University of Chinese Medicine, Hefei 230012, China; 2.Center for Drug Delivery Systems, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201210, China; 3.University of Chinese Academy of Sciences, Beijing 100049, China; 4.School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation, Ministry of Education, Yantai University, Yantai 264005, China; 5.Institut de Sciences Moléculaires d'Orsay, Université Paris-Saclay, UMR CNRS 8214, 91400 Orsay Cedex, France; 6.University of Chinese Academy of Sciences, Beijing 100049, China |
| 推荐引用方式 GB/T 7714 | Xu, Jian,Wu, Li,Guo, Tao,et al. A "Ship-in-a-Bottle" strategy to create folic acid nanoclusters inside the nanocages of γ-cyclodextrin metal-organic frameworks[J]. International journal of pharmaceutics,2018,556:89-96. |
| APA | Xu, Jian.,Wu, Li.,Guo, Tao.,Zhang, Guoqing.,Wang, Caifen.,...&Zhang, Jiwen.(2018).A "Ship-in-a-Bottle" strategy to create folic acid nanoclusters inside the nanocages of γ-cyclodextrin metal-organic frameworks.International journal of pharmaceutics,556,89-96. |
| MLA | Xu, Jian,et al."A "Ship-in-a-Bottle" strategy to create folic acid nanoclusters inside the nanocages of γ-cyclodextrin metal-organic frameworks".International journal of pharmaceutics 556(2018):89-96. |
入库方式： OAI收割
来源：上海药物研究所
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