Heparin-Regulated Prodrug-Type Macromolecular Theranostic Systems for Cancer Therapy
文献类型：期刊论文
| 作者 | Wang, Huiyuan1 ; Moon, Cheol2; Shin, Meong Cheol3; Wang, Yaping1; He, Huining4; Yang, Victor C4; Huang, Yongzhuo1
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| 刊名 | Nanotheranostics
 |
| 出版日期 | 2017 |
| 卷号 | 1期号:1页码:114-130 |
| ISSN号 | 2206-7418 |
| DOI | 10.7150/ntno.18292 |
| 文献子类 | Article;Review |
| 英文摘要 | Heparin is a kind of naturally occurring polymer with excellent biocompatibility and solubility. It is characterized by dense of negative charge, higher than any endogenous components. Heparin can bind with various cationic peptides and proteins, thereby providing a useful noncovalent linkage for building a drug delivery system. As a case in point, heparin/cell-penetrating peptides (CPP) interaction is strong, and remains stable in vivo. They can be used to modify different proteins, respectively, and subsequently, by simply mixing the modified proteins, a protein-protein conjugate can be form via the stable heparin/CPP linkage. This linkage could not be broken unless addition of protamine that bears higher cationic charge density than CPP, and CPP thus can be substituted and released. Of note, heparin is a potent antagonist of CPP, and their binding naturally inhibits CPP-mediated drug cell penetration. Based on this method, we developed a heparin-regulated macromolecular prodrug-type system, termed ATTEMPTS, for drug targeting delivery. In this review article, we mainly summary the application of ATTEMPTS in delivery of various macromolecular drugs for cancer therapy, and also introduce the heparin-regulated nanoprobes for tumor imaging. |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/266339]  |
| 专题 | 药物制剂研究中心 |
| 作者单位 | 1.Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China; 2.College of Pharmacy, Sunchon National University, Republic of Korea; 3.College of Pharmacy and Research Institute of Pharmaceutical Sciences, Gyeongsang National University, Gyeongnam, Republic of Korea; 4.Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnosis, School of Pharmacy, Tianjin Medical University Tianjin 300070, China |
| 推荐引用方式 GB/T 7714 | Wang, Huiyuan,Moon, Cheol,Shin, Meong Cheol,et al. Heparin-Regulated Prodrug-Type Macromolecular Theranostic Systems for Cancer Therapy[J]. Nanotheranostics,2017,1(1):114-130. |
| APA | Wang, Huiyuan.,Moon, Cheol.,Shin, Meong Cheol.,Wang, Yaping.,He, Huining.,...&Huang, Yongzhuo.(2017).Heparin-Regulated Prodrug-Type Macromolecular Theranostic Systems for Cancer Therapy.Nanotheranostics,1(1),114-130. |
| MLA | Wang, Huiyuan,et al."Heparin-Regulated Prodrug-Type Macromolecular Theranostic Systems for Cancer Therapy".Nanotheranostics 1.1(2017):114-130. |
入库方式： OAI收割
来源：上海药物研究所
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