Protein Corona Liposomes Achieve Efficient Oral Insulin Delivery by Overcoming Mucus and Epithelial Barriers
文献类型：期刊论文
| 作者 | Wang, Aohua2; Yang, Tiantian2; Fan, Weiwei2; Yang, Yiwei2; Zhu, Quanlei2; Guo, Shiyan2; Zhu, Chunliu2 ; Yuan, Yongchun1; Zhang, Tao1; Gan, Yong2
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| 刊名 | Advanced healthcare materials
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| 出版日期 | 2018-11-28 |
| 页码 | e1801123 |
| ISSN号 | 2192-2659 |
| DOI | 10.1002/adhm.201801123 |
| 文献子类 | Article |
| 英文摘要 | Oral delivery of peptide/protein drugs has attracted worldwide attention due to its good patient compliance and convenience of administration. Orally administered nanocarriers always encounter the rigorous defenses of the gastrointestinal tract, which mainly consist of mucus and epithelium barriers. However, diametrically opposite surface properties of nanocarriers are required for good mucus penetration and high epithelial uptake. Here, bovine serum albumin (BSA) is adsorbed to cationic liposomes (CLs) to form protein corona liposomes (PcCLs). The aim of using PcCLs is to conquer the mucus and epithelium barriers, eventually improving the oral bioavailability of insulin. Investigations using in vitro and in vivo experiments show that the uptake amounts and transepithelial permeability of PcCLs are 3.24- and 7.91-fold higher than that of free insulin, respectively. Further study of the behavior of PcCLs implies that BSA corona can be shed from PcCLs as they cross the mucus layer, which results in the exposure of CLs to improve the transepithelial transport. Intrajejunal administration of PcCLs in type I diabetic rats produces a remarkable hypoglycemic effect and increases the oral bioavailability up to 11.9%. All of these results imply that PcCLs may provide a new insight into the method for oral insulin delivery by overcoming the multiple barriers. |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/266776]  |
| 专题 | 药物制剂研究中心 |
| 作者单位 | 1.Shanghai Institute of Technical Physics, Chinese Academy of Sciences, No. 500, Yutian Road, Shanghai, 200083, China 2.Center for Pharmaceutics Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China; |
| 推荐引用方式 GB/T 7714 | Wang, Aohua,Yang, Tiantian,Fan, Weiwei,et al. Protein Corona Liposomes Achieve Efficient Oral Insulin Delivery by Overcoming Mucus and Epithelial Barriers[J]. Advanced healthcare materials,2018:e1801123. |
| APA | Wang, Aohua.,Yang, Tiantian.,Fan, Weiwei.,Yang, Yiwei.,Zhu, Quanlei.,...&Gan, Yong.(2018).Protein Corona Liposomes Achieve Efficient Oral Insulin Delivery by Overcoming Mucus and Epithelial Barriers.Advanced healthcare materials,e1801123. |
| MLA | Wang, Aohua,et al."Protein Corona Liposomes Achieve Efficient Oral Insulin Delivery by Overcoming Mucus and Epithelial Barriers".Advanced healthcare materials (2018):e1801123. |
入库方式： OAI收割
来源：上海药物研究所
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