Fabrication of β-cyclodextrin and sialic acid copolymer by single pot reaction to site specific drug delivery
文献类型：期刊论文
| 作者 | Singh, Parbeen1,2; Ren, Xiaohong1; He, Yaping1,2; Wu, Li1; Wang, Caifen1; Li, Haiyan1 ; Singh, Vikramjeet1,3; Zhang, Jiwen1,2
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| 刊名 | Arabian Journal of Chemistry
 |
| 出版日期 | 2018 |
| ISSN号 | 18785352 |
| DOI | 10.1016/j.arabjc.2017.11.011 |
| 文献子类 | Article |
| 英文摘要 | The fabrication of supramolecular host in combination biomolecules is an interesting idea in modern drug delivery for development of new polymer with advanced chemical and biological properties. Herein, hyper-crosslinked copolymer was fabricated from β-cyclodextrin (β-CD) and sialic acid (SA) monomers, which can be undoublty considered as a new class of copolymer. The as-synthesized copolymer has complexation properties, which could cover the drug within the structure and deliver to the site of action. The well-known inclusion capability of β-CD and targeted efficacy of SA made it more appropriate for targeted drug delivery. The copolymer was characterized using a wide range of spectroscopic and microscopic techniques such as synchrotron radiation based FTIR spectroscopy (SR-FTIR), differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), and powder X-ray diffraction (PXRD). The surface area and porosity were calculated by using Nitrogen adsorption method. Doxorubicin (Dox) was selected as a model drug to evaluate the loading efficiency and cellular penetration ability of the copolymer. The copolymer showed high adsorption towards Dox with no significant cytotoxic effects on HeLa cells as proved by cell viability assay. High cellular penetration of Dox loaded copolymer was also recorded by confocal microscopy when compared with free Dox in HeLa cells at 4 h of exposure. Thus, β-CD-SA copolymer could be a useful carrier for targeted drug delivery of cancer and has the potential for further investigation in viral and nervous disease due to the targeting ability of SA. |
| 语种 | 英语 |
| 出版者 | Elsevier B.V. |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/266971]  |
| 专题 | 药物制剂研究中心 |
| 通讯作者 | Singh, Vikramjeet |
| 作者单位 | 1.Center for Drug Delivery System, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai; 201203, China; 2.University of Chinese Academy of Sciences, Beijing; 100049, China; 3.School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou; 510006, China |
| 推荐引用方式 GB/T 7714 | Singh, Parbeen,Ren, Xiaohong,He, Yaping,et al. Fabrication of β-cyclodextrin and sialic acid copolymer by single pot reaction to site specific drug delivery[J]. Arabian Journal of Chemistry,2018. |
| APA | Singh, Parbeen.,Ren, Xiaohong.,He, Yaping.,Wu, Li.,Wang, Caifen.,...&Zhang, Jiwen.(2018).Fabrication of β-cyclodextrin and sialic acid copolymer by single pot reaction to site specific drug delivery.Arabian Journal of Chemistry. |
| MLA | Singh, Parbeen,et al."Fabrication of β-cyclodextrin and sialic acid copolymer by single pot reaction to site specific drug delivery".Arabian Journal of Chemistry (2018). |
入库方式： OAI收割
来源：上海药物研究所
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