Applicability of a natural swelling matrix as the propellant of osmotic pump tablets
文献类型：期刊论文
| 作者 | Wu Li1; Li Haiyan2 ; Yin Xianzhen2; Li Ying1; Chen Jianxiu1; Hu Rongfeng1; Zhang Jiwen1
|
| 刊名 | Acta Pharmaceutica Sinica
 |
| 出版日期 | 2013 |
| 卷号 | 48期号:8页码:1319-1324 |
| 关键词 | osmotic pump tablet boat-fruited sterculia seed propellant water uptake swelling viscosity |
| ISSN号 | 0513-4870 |
| 其他题名 | 天然膨胀性基质作为渗透泵片推动剂的适用性研究 |
| 文献子类 | Article |
| 英文摘要 | The purpose of this study is to investigate the applicability of a natural swelling matrix derived from boat-fruited sterculia seed (SMS) as the propellant of osmotic pump tablets. The sugar components, static swelling, water uptake and viscosity of SMS were determined and compared with that of polythylene oxide (WSR-N10 and WSR-303). Both ribavirin and glipizide were used as water-soluble and water-insoluble model drugs. Then, the monolayer osmotic pump tablets of ribavirin and the bilayer osmotic pump tablets of glipizide were prepared using SMS as the osmotically active substance and propellant. SMS was mainly composed of rhamnose, arabinose, xylose and galactose and exhibited relatively high swelling ability. The area of the disintegrated matrix tablet was 20.1 times as that at initial after swelling for 600 s. SMS swelled rapidly and was fully swelled (0.5%) in aqueous solution with relative low viscosity (3.66 0.03) mPa·s at 25 ℃. The monolayer osmotic pump tablets of ribavirin and the bilayer osmotic pump tablets of glipizide using SMS as propellant exhibited typical drug release features of osmotic pumps. In conclusion, the swelling matrix derived from boat-fruited sterculia seed, with low viscosity and high swelling, is a potential propellant in the application of osmotic pump tablets. |
| 资助项目 | 国家自然科学基金资助项目[00000000] ; 国家科技重大专项资助项目[00000000] |
| WOS研究方向 | Pharmacology & Pharmacy (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:4908857 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/267764]  |
| 专题 | 药物制剂研究中心 分子影像中心（筹） |
| 通讯作者 | Zhang Jiwen |
| 作者单位 | 1.Anhui University of Traditional Chinese Medicine, Hefei, Anhui 230038, China.; 2.Shanghai Institute of Materia Medica,Chinese Academy of Sciences, Shanghai 201203, China. |
| 推荐引用方式 GB/T 7714 | Wu Li,Li Haiyan,Yin Xianzhen,et al. Applicability of a natural swelling matrix as the propellant of osmotic pump tablets[J]. Acta Pharmaceutica Sinica,2013,48(8):1319-1324. |
| APA | Wu Li.,Li Haiyan.,Yin Xianzhen.,Li Ying.,Chen Jianxiu.,...&Zhang Jiwen.(2013).Applicability of a natural swelling matrix as the propellant of osmotic pump tablets.Acta Pharmaceutica Sinica,48(8),1319-1324. |
| MLA | Wu Li,et al."Applicability of a natural swelling matrix as the propellant of osmotic pump tablets".Acta Pharmaceutica Sinica 48.8(2013):1319-1324. |
入库方式： OAI收割
来源：上海药物研究所
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