Absorption of multi-components from Coptidis Rhizoma in Caco-2 monolayer model and their interactions
文献类型：期刊论文
| 作者 | Qi Juan1; Guo Tao2; Li Haiyan2 ; Zhang Xueju2; Yin Xianzhen2; Ge Weihong1; Zhang Jiwen2
|
| 刊名 | Chinese Traditional and Herbal Drugs
 |
| 出版日期 | 2013 |
| 卷号 | 44期号:13页码:1801-1806 |
| 关键词 | aqueous extract of Coptidis Rhizoma Caco-2 monolayer model multi-component interactions apparent permeability coefficient data fitting |
| ISSN号 | 0253-2670 |
| 其他题名 | 黄连多组分在Caco-2细胞单层模型的吸收及其相互作用 |
| 文献子类 | Article |
| 英文摘要 | Objective To research the correlation between compositions and absorption of the multi-components in Coptidis Rhizoma and to explore the methods suitable for identifying the interactions of multi-components in Coptidis Rhizoma during the absorption process. Methods Samples of various compositions by their different combinations of each component in Coptidis Rhizoma were designed and prepared using Caco-2 monolayer model. Using HPLC method for the simultaneous quantitative determination, taking the inherent apparent permeability coefficients (P_(app)) by the individual transport of each component as reference, the least square multi-linear regression was used for data fitting to obtain the correlation between interaction intensity of P_(app) and concentration of each component by their different combinations and to analyze the interaction type and intensity of multi-components during the absorption. Results The quantitative relationship of multi-component interactions for coptisine, jatrorrhizine, berberine, and palmatine was obtained, respectively. The main contributors for the multi-component interaction, including single component and interactive products of the different components, were also identified. The quantitative relationship affecting the absorption was also obtained. Conclusion A well-designed method for studying the multi-component interactions of Coptidis Rhizoma using mathematical method is practicable. |
| 资助项目 | 国家科技重大专项资助项目[00000000] |
| WOS研究方向 | Pharmacology & Pharmacy (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:4888008 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/267768]  |
| 专题 | 药物制剂研究中心 |
| 通讯作者 | Zhang Jiwen |
| 作者单位 | 1.Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, China.; 2.Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. |
| 推荐引用方式 GB/T 7714 | Qi Juan,Guo Tao,Li Haiyan,et al. Absorption of multi-components from Coptidis Rhizoma in Caco-2 monolayer model and their interactions[J]. Chinese Traditional and Herbal Drugs,2013,44(13):1801-1806. |
| APA | Qi Juan.,Guo Tao.,Li Haiyan.,Zhang Xueju.,Yin Xianzhen.,...&Zhang Jiwen.(2013).Absorption of multi-components from Coptidis Rhizoma in Caco-2 monolayer model and their interactions.Chinese Traditional and Herbal Drugs,44(13),1801-1806. |
| MLA | Qi Juan,et al."Absorption of multi-components from Coptidis Rhizoma in Caco-2 monolayer model and their interactions".Chinese Traditional and Herbal Drugs 44.13(2013):1801-1806. |
入库方式： OAI收割
来源：上海药物研究所
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