Preparation and in vitro Antitumor Activity of Irinotecan Hydrochloride Liposomes
文献类型：期刊论文
| 作者 | Fan Jitao2; Cao Haiqiang1; Liu Zeying3; Li Yaping2 ; Chen Lingli1
|
| 刊名 | Chinese Journal of Pharmaceuticals
 |
| 出版日期 | 2013 |
| 卷号 | 44期号:6页码:576-580 |
| 关键词 | irinotecan hydrochloride liposome preparation ammonium sulfate gradient method in vitro antitumor activity |
| ISSN号 | 1001-8255 |
| 其他题名 | 盐酸伊立替康脂质体的制备及体外抗肿瘤活性 |
| 文献子类 | Article |
| 英文摘要 | The irinotecan hydrochloride liposomes with the mean particle size and entrapment efficiency of (45.312.6) nm and (93.80.7)% were prepared by ammonium sulfate gradient method. The drug was released completely from the liposomes within 120 h in phosphate buffer (pH 7.4) in a manner of sustained release. Compared with the free drug, the prepared liposomes showed slightly higher in vitro cytotoxicity on human colorectal cancer HT-29 cells at relatively high concentration (above 25 mug/ml). The IC_(50) values of the product and free drug were 28.1 and 33.0 mug/ml, respectively. Both liposomes and free drug could induce apoptosis of HT-29 cells at the drug concentration of 30 mug/ml, but the liposomes exhibited a stronger effect on the induction of cell apoptosis than free drug. |
| WOS研究方向 | Pharmacology & Pharmacy (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:4879578 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/267771]  |
| 专题 | 药物制剂研究中心 |
| 作者单位 | 1.Center for Drug Delivery System, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.; 2.School of Pharmacy, Jiangsu University, Zhenjiang, Jiangsu 212013, China.; 3.School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China. |
| 推荐引用方式 GB/T 7714 | Fan Jitao,Cao Haiqiang,Liu Zeying,et al. Preparation and in vitro Antitumor Activity of Irinotecan Hydrochloride Liposomes[J]. Chinese Journal of Pharmaceuticals,2013,44(6):576-580. |
| APA | Fan Jitao,Cao Haiqiang,Liu Zeying,Li Yaping,&Chen Lingli.(2013).Preparation and in vitro Antitumor Activity of Irinotecan Hydrochloride Liposomes.Chinese Journal of Pharmaceuticals,44(6),576-580. |
| MLA | Fan Jitao,et al."Preparation and in vitro Antitumor Activity of Irinotecan Hydrochloride Liposomes".Chinese Journal of Pharmaceuticals 44.6(2013):576-580. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。