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Real-time UV imaging of chloramphenicol intrinsic dissolution characteristics from ophthalmic in situ gel

文献类型：期刊论文

作者Chen Jianxiu2; Guo Zhen1; Li Haiyan1; Wu Li2; He Zhonggui3; Hu Rongfeng2; Zhang Jiwen2
刊名Acta Pharmaceutica Sinica
出版日期2013
卷号48期号:7页码:1156-1163
关键词in situ gel intrinsic dissolution rate real-time UV imaging chloramphenicol thermosensitive in situ gel pH sensitive in situ gel
ISSN号0513-4870
其他题名实时紫外成像研究氯霉素眼用原位凝胶的固有溶出特征
文献子类Article
英文摘要In this paper, chloramphenicol was selected as a model drug to prepare in situ gels. The intrinsic dissolution rate of chloramphenicol from in situ gel was evaluated using the surface dissolution imaging system. The results indicated that intrinsic dissolution rate of chloramphenicol thermosensitive in situ gel decreased significantly when the poloxamer concentration increased. The addition of the thickener reduced the intrinsic dissolution rate of chloramphenicol thermosensitive gel, wherein carbomer had the most impact. Different dilution ratios of simulated tear fluid greatly affected gel temperature, and had little influence on the intrinsic dissolution rate of chloramphenicol from the thermosensitive in situ gel. The pH of simulated tear fluid had little influence on the intrinsic dissolution rate of chloramphenicol thermosensitive in situ gel. For the pH sensitive in situ gel, the dissolution rates of chloramphenicol in weak acidic and neutral simulated tear fluids were slower than that in weak alkaline simulated tear fluid. In conclusion, the intrinsic dissolution of chloramphenicol from in situ gel was dependent on formulation and physiological factors. With advantages of small volume sample required and rapid detection, the UV imaging method can be an efficient tool for the evaluation of drug release characteristics of ophthalmic in situ gel.
资助项目国家自然科学基金资助项目[00000000] ; 国家科技重大专项资助项目[00000000]
WOS研究方向Pharmacology & Pharmacy (provided by Clarivate Analytics)
语种中文
CSCD记录号CSCD:4882836
源URL[http://119.78.100.183/handle/2S10ELR8/267774]  
专题药物制剂研究中心
通讯作者Zhang Jiwen
作者单位1.Shanghai Institute of Materia Medica,Chinese Academy of Sciences, Shanghai 201203, China.;
2.Anhui University of Traditional Chinese Medicine, Hefei, Anhui 230038, China.;
3.Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, China.
推荐引用方式
GB/T 7714		 Chen Jianxiu,Guo Zhen,Li Haiyan,et al. Real-time UV imaging of chloramphenicol intrinsic dissolution characteristics from ophthalmic in situ gel[J]. Acta Pharmaceutica Sinica,2013,48(7):1156-1163.
APA Chen Jianxiu.,Guo Zhen.,Li Haiyan.,Wu Li.,He Zhonggui.,...&Zhang Jiwen.(2013).Real-time UV imaging of chloramphenicol intrinsic dissolution characteristics from ophthalmic in situ gel.Acta Pharmaceutica Sinica,48(7),1156-1163.
MLA Chen Jianxiu,et al."Real-time UV imaging of chloramphenicol intrinsic dissolution characteristics from ophthalmic in situ gel".Acta Pharmaceutica Sinica 48.7(2013):1156-1163.

入库方式： OAI收割

来源：上海药物研究所

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