Preparation and Pharmacokinetics of Simvastatin Nanostructured Lipid Carriers in Rats
文献类型：期刊论文
| 作者 | Liu Zeying1; Shen Shuhui1; Jiang Shijun1; Zhang Zhiwen2 ; Cui Jingbin1
|
| 刊名 | Chinese Journal of Pharmaceuticals
 |
| 出版日期 | 2013 |
| 卷号 | 44期号:1页码:46-49 |
| 关键词 | simvastatin simvastatin acid nanostructured lipid carrier preparation absorption pharmacokinetics |
| ISSN号 | 1001-8255 |
| 其他题名 | 辛伐他汀纳米脂质载体的制备及大鼠体内药动学 |
| 文献子类 | Article |
| 英文摘要 | Simvastatin loaded nanostructured lipid carriers (1-NLC) were prepared by emulsification solvent evaporation technique. The physicochemical properties, in situ intestinal absorption and pharmacokinetic behavior in rats of 1-NLC were investigated. The results showed that 1-NLC was nanometer-sized particle with the mean diameter of (72.147.2)nm and the entrapment efficiency of 1-NLC was (94.62.5)% with the drug loading of (5.780.57)%. Compared with bulk drug suspension group, the absorption rate constant in duodenum, jejunum and ileum of 1-NLC group were increased by 50%, 130% and 60%, respectively. The results of pharmacokinetics in rats showed the oral bioavailability of simvastatin and its active metabolite, simvastatin acid, in 1-NLC group were 222% and 269% compared with the suspension group. |
| 资助项目 | 国家重大科学研究计划项目[00000000] |
| WOS研究方向 | Pharmacology & Pharmacy (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:4782007 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/267790]  |
| 专题 | 药物制剂研究中心 |
| 作者单位 | 1.School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China.; 2.Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. |
| 推荐引用方式 GB/T 7714 | Liu Zeying,Shen Shuhui,Jiang Shijun,et al. Preparation and Pharmacokinetics of Simvastatin Nanostructured Lipid Carriers in Rats[J]. Chinese Journal of Pharmaceuticals,2013,44(1):46-49. |
| APA | Liu Zeying,Shen Shuhui,Jiang Shijun,Zhang Zhiwen,&Cui Jingbin.(2013).Preparation and Pharmacokinetics of Simvastatin Nanostructured Lipid Carriers in Rats.Chinese Journal of Pharmaceuticals,44(1),46-49. |
| MLA | Liu Zeying,et al."Preparation and Pharmacokinetics of Simvastatin Nanostructured Lipid Carriers in Rats".Chinese Journal of Pharmaceuticals 44.1(2013):46-49. |
入库方式： OAI收割
来源：上海药物研究所
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