Preliminary study on pH-sensitive lipid bilayer-coated mesoporous silica nanoparticles as a novel drug carrier for antitumor drug
文献类型：期刊论文
| 作者 | Li Feifei2; Zhang Xinxin1 ; Guo Shiyan1; Gan Yong1; Li Juan2
|
| 刊名 | Acta Pharmaceutica Sinica
 |
| 出版日期 | 2013 |
| 卷号 | 48期号:2页码:291-297 |
| 关键词 | mesoporous silica nanoparticle core-shell nanoparticle pH sensitive irinotecan drug carrier |
| ISSN号 | 0513-4870 |
| 其他题名 | pH敏感性的脂质-介孔硅核/壳纳米粒作为抗肿瘤药物新型载体的初步研究 |
| 文献子类 | Article |
| 英文摘要 | This study plans to prepare lipid bilayer-coated mesoporous silica nanoparticles (LMSNs) which are pH sensitive with core-shell structure to improve the tumor cell lethality of antitumor drug. The lipid coated mesoporous silica nanoparticles loaded with irinotecan (CPT-11) (CPT-11-LMSNs) were prepared by hot waterfilm hydration method, and the characterized its morphology, particle size and release in vitro. Meanwhile, the intracellular uptake and cell toxicity of CPT-11-LMSNs and intracellular accumulation of CPT-11 were evaluated on human breast carcinoma cell line (MCF-7). The results indicated that the mean diameter of the spherical LMSNs was (120.27 5.91) nm. The slow release in simulated normal physiological conditions and a rapid release under simulated intracellular condition demonstrated the pH sensitivity of CPT-11-MSNs in vitro. Moreover, the CPT-11-LMSN could improve the intracellular CPT-11 cumulant 2.1 times and reduce half maximal inhibitory concentration (IC_(50)) values of CPT-11 1.4 times compared with CPT-11-MSNs, demonstrating a stronger cell lethality. |
| 资助项目 | 国家自然科学基金资助项目[00000000] ; 河北省自然科学基金资助项目[00000000] |
| WOS研究方向 | Pharmacology & Pharmacy (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:4764396 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/267797]  |
| 专题 | 药物制剂研究中心 |
| 作者单位 | 1.Shanghai Institute of Material Medica,Chinese Academy of Sciences, Shanghai 201203, China. 2.Department of Pharmaceutics,China Pharmaceutical University, Nanjing, Jiangsu 210009, China.; |
| 推荐引用方式 GB/T 7714 | Li Feifei,Zhang Xinxin,Guo Shiyan,et al. Preliminary study on pH-sensitive lipid bilayer-coated mesoporous silica nanoparticles as a novel drug carrier for antitumor drug[J]. Acta Pharmaceutica Sinica,2013,48(2):291-297. |
| APA | Li Feifei,Zhang Xinxin,Guo Shiyan,Gan Yong,&Li Juan.(2013).Preliminary study on pH-sensitive lipid bilayer-coated mesoporous silica nanoparticles as a novel drug carrier for antitumor drug.Acta Pharmaceutica Sinica,48(2),291-297. |
| MLA | Li Feifei,et al."Preliminary study on pH-sensitive lipid bilayer-coated mesoporous silica nanoparticles as a novel drug carrier for antitumor drug".Acta Pharmaceutica Sinica 48.2(2013):291-297. |
入库方式： OAI收割
来源：上海药物研究所
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