The Penetrating Activity of Nano-silver Mediated by Cell Penetrating Peptide
文献类型：期刊论文
| 作者 | Liu Jinhua3; Guo Qianqian3; Hua Haiying3; Yuan Bo1; Zhao Yongxing3; Huang Yongzhuo2
|
| 刊名 | Chinese Journal of Modern Applied Pharmacy
 |
| 出版日期 | 2012 |
| 卷号 | 29期号:10页码:865-868 |
| 关键词 | MCF-7/ADR silver nanoparticles cell penetrating peptide MCF-7/ADR cell uptake |
| ISSN号 | 1007-7693 |
| 其他题名 | 穿膜肽提高纳米银穿膜活性的研究 |
| 文献子类 | Article |
| 英文摘要 | OBJECTIVE To assess the intracellular delivery efficiency of silver nanoparticles surface-modified by cell penetrating peptides(TAT) in human breast cancer drug doxorubicin-resistant MCF-7/ADR cells. METHODS Silver nanoparticle(AgNP) was prepared by chemical reduction and was modified with TAT by Ag-S covalent bond. The TAT-AgNP was characterized using particle analyzer, TEM, laser confocal microsopy, and TGA, and TAT-mediated cellular uptake were measured using FACS. RESULTS The AgNP with diameter below 10 nm was successfully synthesized. The cell penetrating activity of TAT-modified AgNP (AgNP-TAT) was higher than that of AgNP. CONCLUSION The cell penetrating activity of AgNP was significantly improved by modification with TAT. |
| 资助项目 | 国家自然科学基金[00000000] |
| WOS研究方向 | Pharmacology & Pharmacy (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:4693838 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/267809]  |
| 专题 | 药物制剂研究中心 |
| 通讯作者 | Huang Yongzhuo |
| 作者单位 | 1.Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Ji'nan, Shandong 250000, China.; 2.Shanghai Institute of Materia Medica Chinese Academy of Sciences, Shanghai 201203, China. 3.Zhengzhou University, Zhengzhou, Henan 450001, China.; |
| 推荐引用方式 GB/T 7714 | Liu Jinhua,Guo Qianqian,Hua Haiying,et al. The Penetrating Activity of Nano-silver Mediated by Cell Penetrating Peptide[J]. Chinese Journal of Modern Applied Pharmacy,2012,29(10):865-868. |
| APA | Liu Jinhua,Guo Qianqian,Hua Haiying,Yuan Bo,Zhao Yongxing,&Huang Yongzhuo.(2012).The Penetrating Activity of Nano-silver Mediated by Cell Penetrating Peptide.Chinese Journal of Modern Applied Pharmacy,29(10),865-868. |
| MLA | Liu Jinhua,et al."The Penetrating Activity of Nano-silver Mediated by Cell Penetrating Peptide".Chinese Journal of Modern Applied Pharmacy 29.10(2012):865-868. |
入库方式： OAI收割
来源：上海药物研究所
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