Preparation and characterization of irinotecan hydrochloride loaded PEO-PPO-PEO micelles and its mechanism of decreasing drug intestinal toxicity
文献类型：期刊论文
| 作者 | Zhang Xinxin ; Guo Shiyan; Li Feifei; Gan Yong
|
| 刊名 | Acta Pharmaceutica Sinica
 |
| 出版日期 | 2012 |
| 卷号 | 47期号:11页码:1534-1540 |
| 关键词 | PEO-PPO-PEO irinotecan micelle breast cancer resistance protein PEO-PPO-PEO diarrhea |
| ISSN号 | 0513-4870 |
| 其他题名 | 伊立替康PEO-PPO-PEO胶束的制备和表征及其降低药物消化道毒性的机制研究 |
| 文献子类 | Article |
| 英文摘要 | In this work, we developed PEO-PPO-PEO micelles loaded with irinotecan hydrochloride (CPT-11) using breast cancer resistance protein (BCRP) inhibitory material PEO_(20)-PPO_(70)-PEO_(20), and studied its mechanism of decreasing CPT-11 induced delayed diarrhea and intestinal toxicity. BCRP-overexpressing MDCKII (MDCKII/BCRP) cells were used to evaluate the effect of PEO_(20)-PPO_(70)-PEO_(20) and PEO-PPO-PEO micelles on transmembrane transport of CPT-11 in vitro. The biliary excretion, delayed diarrhea and intestinal damage of CPT-11 loaded PEO-PPO-PEO micelles of rats were investigated. The results showed that the obtained micelles could decrease the biliary excretion of CPT-11, ameliorate delayed diarrhea and intestinal toxicity of rats through inhibiting BCRP-mediated CPT-11 efflux. PEO-PPO-PEO micelles were promising carriers to reduce intestinal toxicity of CPTs. |
| 资助项目 | 国家自然科学基金资助项目[00000000] ; 河北省自然科学基金资助项目[00000000] |
| WOS研究方向 | Pharmacology & Pharmacy (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:4665972 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/267817]  |
| 专题 | 药物制剂研究中心 |
| 通讯作者 | Gan Yong |
| 作者单位 | Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. |
| 推荐引用方式 GB/T 7714 | Zhang Xinxin,Guo Shiyan,Li Feifei,et al. Preparation and characterization of irinotecan hydrochloride loaded PEO-PPO-PEO micelles and its mechanism of decreasing drug intestinal toxicity[J]. Acta Pharmaceutica Sinica,2012,47(11):1534-1540. |
| APA | Zhang Xinxin,Guo Shiyan,Li Feifei,&Gan Yong.(2012).Preparation and characterization of irinotecan hydrochloride loaded PEO-PPO-PEO micelles and its mechanism of decreasing drug intestinal toxicity.Acta Pharmaceutica Sinica,47(11),1534-1540. |
| MLA | Zhang Xinxin,et al."Preparation and characterization of irinotecan hydrochloride loaded PEO-PPO-PEO micelles and its mechanism of decreasing drug intestinal toxicity".Acta Pharmaceutica Sinica 47.11(2012):1534-1540. |
入库方式： OAI收割
来源：上海药物研究所
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