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Correlation of Fuzilizhong chemome release from osmotic pump tablets and intrinsic dissolution characteristics from powders

文献类型：期刊论文

作者Chen Fangwei1; Guo Zhen2; Li Haiyan2; Shi Senlin1; Zhang Jiwen2
刊名Journal of China Pharmaceutical University
出版日期2012
卷号43期号:4页码:329-333
关键词osmotic pump tablets chemomic release intrinsic dissolution rate
ISSN号1000-5048
其他题名附子理中渗透泵片释放度与粉体固有溶出特征的相关性研究
文献子类Article
英文摘要To investigate the effects of formula factors such as osmotic agents,disintegrating agents and preparation process on the Fuzilizhong chemome release from osmotic pump tablets.The total ultraviolet absorbance value of all the components was as the release indexes,the surface dissolution/erosion imaging system was used to determine the intrinsic dissolution characteristics of the powders.The correlation between the chemome release from osmotic pump tablets and the intrinsic dissolution characteristics of the powders was established.From the results of the chemomic release study,the optimized formulation of the osmotic pump tablets had lactose and sodium chloride(weight ratio 1∶1) as osmotic agents,5% crosslinking polyvingypyrrolidone(PVPP) as disintegrating agent.It was indicated from the correlation analysis that there was a negative correlation between the intrinsic dissolution rate of powders and the dissolution rate of osmotic pump tablets,and a linear correlation between powders intrinsic dissolution rate and the amount of PVPP.However,excessive PVPP could affect the maximum cumulative release.
资助项目国家自然科学基金资助项目[00000000] ; 中国科学院知识创新工程重要方向项目资助[00000000] ; 浙江省重点科技创新团队项目资助[00000000] ; 上海市科委科研计划资助项目[00000000]
WOS研究方向Pharmacology & Pharmacy (provided by Clarivate Analytics)
语种中文
CSCD记录号CSCD:4606282
源URL[http://119.78.100.183/handle/2S10ELR8/267826]  
专题药物制剂研究中心
通讯作者Zhang Jiwen
作者单位1.Zhejiang University of Chinese Medicine, Hangzhou, Zhejiang 310053, China.;
2.Shanghai Institute of Materia Medica,Chinese Academy of Sciences, Shanghai 201203, China.
推荐引用方式
GB/T 7714		 Chen Fangwei,Guo Zhen,Li Haiyan,et al. Correlation of Fuzilizhong chemome release from osmotic pump tablets and intrinsic dissolution characteristics from powders[J]. Journal of China Pharmaceutical University,2012,43(4):329-333.
APA Chen Fangwei,Guo Zhen,Li Haiyan,Shi Senlin,&Zhang Jiwen.(2012).Correlation of Fuzilizhong chemome release from osmotic pump tablets and intrinsic dissolution characteristics from powders.Journal of China Pharmaceutical University,43(4),329-333.
MLA Chen Fangwei,et al."Correlation of Fuzilizhong chemome release from osmotic pump tablets and intrinsic dissolution characteristics from powders".Journal of China Pharmaceutical University 43.4(2012):329-333.

入库方式： OAI收割

来源：上海药物研究所

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