An oligopeptide improves solubility of paclitaxel by non-covalent interaction
文献类型：期刊论文
| 作者 | Liu Wei1; Guo Tao2; Ge Jingwen1; Li Haiyan2 ; Xu Xuejun2; Sun Lixin1; Zhang Jiwen2
|
| 刊名 | Acta Pharmaceutica Sinica
 |
| 出版日期 | 2012 |
| 卷号 | 47期号:7页码:947-952 |
| 关键词 | oligopeptide paclitaxel drug design molecular docking solubilization |
| ISSN号 | 0513-4870 |
| 其他题名 | 非共价相互作用增加紫杉醇溶解度的寡肽研究 |
| 文献子类 | Article |
| 英文摘要 | Based on the principle of non-covalent interactions between oligopeptides and paclitaxel for improving the solubility of paclitaxel,an oligopeptide,N terminal-W(L)-FFGREKD-C terminal(W8),was designed and the solubilization effect of W8 on paclitaxel was detected through experiments.The binding efficiency and the possible optimal conformation were optimized by molecular docking program.The solubilization effect of W8 on paclitaxel was determined by RP-HPLC.And the solubilization mechanism of oligopeptide to paclitaxel was proposed at molecular level.It was indicated from the docking result that there existed pi-pi interactions and several hydrogen-bond interactions between the oligopeptide and paclitaxel.After being solubilized by the oligopeptide,the aqueous solubility of paclitaxel was increased to 28 times.This study provided basis for further research of the solubilization of paclitaxel by oligopeptide and confirmed a novel approach for the design of safe oligopeptide solubilizing excipient. |
| 资助项目 | 国际科技合作项目[00000000] ; 国家自然科学基金资助项目[00000000] |
| WOS研究方向 | Pharmacology & Pharmacy (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:4579583 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/267830]  |
| 专题 | 药物制剂研究中心 |
| 通讯作者 | Zhang Jiwen |
| 作者单位 | 1.Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, China.; 2.Shanghai Institute of Materia Medica,Chinese Academy of Sciences, Shanghai 201203, China. |
| 推荐引用方式 GB/T 7714 | Liu Wei,Guo Tao,Ge Jingwen,et al. An oligopeptide improves solubility of paclitaxel by non-covalent interaction[J]. Acta Pharmaceutica Sinica,2012,47(7):947-952. |
| APA | Liu Wei.,Guo Tao.,Ge Jingwen.,Li Haiyan.,Xu Xuejun.,...&Zhang Jiwen.(2012).An oligopeptide improves solubility of paclitaxel by non-covalent interaction.Acta Pharmaceutica Sinica,47(7),947-952. |
| MLA | Liu Wei,et al."An oligopeptide improves solubility of paclitaxel by non-covalent interaction".Acta Pharmaceutica Sinica 47.7(2012):947-952. |
入库方式： OAI收割
来源：上海药物研究所
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