Preparation of Probucol Loaded Mixed Micelles and Its Pharmacokinetic Behavior In Rats
文献类型：期刊论文
| 作者 | Jiang Shijun2; Liu Xiujie2; Huang Jian1; Gao Fang1; Gu Wangwen1 ; Cui Jingbin2
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| 刊名 | Chinese Journal of Modern Applied Pharmacy
 |
| 出版日期 | 2012 |
| 卷号 | 29期号:1页码:46-49 |
| 关键词 | probucol mixed micelle differential scanning calorimetry X-ray diffraction bioavailability |
| ISSN号 | 1007-7693 |
| 其他题名 | 普罗布考混合胶束的制备及其大鼠体内药动学研究 |
| 文献子类 | Article |
| 英文摘要 | OBJECTIVE Development of probucol loaded mixed micelles(PMM) for enhancing its oral bioavailability.METHODS PMM was prepared with soybean phosphatidylcholine(EPC) and sodium deoxycholate(SD) by a co-precipitation method.The in vitro properties and in vivo pharmacokinetic behavior of PMM was evaluated.RESULTS The formulation of PMM was optimized as EPC︰SD︰probucol(3︰4︰1).PMM was self-assembled with average diameter of 82.28 nm and polydispersity index of 0.179.Probucol may exhibit as amorphous state in PMM.The in vivo pharmacokinetical results indicated that the peak concentration(Cmax) and area under concentration-time curve(AUC) was significantly improved by 2.28-fold and 4.43-fold,respectively.CONCLUSION The oral bioavailability of probucol was significantly improved by PMM,which could be potential for enhancing the oral absorption of insoluble drugs. |
| 资助项目 | 国家重点基础研究发展计划[00000000] |
| WOS研究方向 | Pharmacology & Pharmacy (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:4444320 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/267852]  |
| 专题 | 药物制剂研究中心 |
| 作者单位 | 1.Shanghai Institute of Materia Medica,Chinese Academy of Sciences, Shanghai 201203, China. 2.School of Pharmacy,East China University of Science and Technology, Shanghai 200237, China.; |
| 推荐引用方式 GB/T 7714 | Jiang Shijun,Liu Xiujie,Huang Jian,et al. Preparation of Probucol Loaded Mixed Micelles and Its Pharmacokinetic Behavior In Rats[J]. Chinese Journal of Modern Applied Pharmacy,2012,29(1):46-49. |
| APA | Jiang Shijun,Liu Xiujie,Huang Jian,Gao Fang,Gu Wangwen,&Cui Jingbin.(2012).Preparation of Probucol Loaded Mixed Micelles and Its Pharmacokinetic Behavior In Rats.Chinese Journal of Modern Applied Pharmacy,29(1),46-49. |
| MLA | Jiang Shijun,et al."Preparation of Probucol Loaded Mixed Micelles and Its Pharmacokinetic Behavior In Rats".Chinese Journal of Modern Applied Pharmacy 29.1(2012):46-49. |
入库方式： OAI收割
来源：上海药物研究所
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