Preparation and characterization of dihydroartemisinin/hydroxypropyl-beta-cyclodextrin inclusion complex
文献类型：期刊论文
| 作者 | Chen Fangwei2; Guo Tao2; Li Haiyan2 ; Guo Zhen2; He Zhonggui1; Shi Senlin3; Zhang Jiwen2
|
| 刊名 | Acta Pharmaceutica Sinica
 |
| 出版日期 | 2012 |
| 卷号 | 47期号:4页码:529-534 |
| 关键词 | dihydroartemisinin hydroxypropyl-beta-cyclodextrin preparation characterization molecular simulation |
| ISSN号 | 0513-4870 |
| 其他题名 | 双氢青蒿素羟丙基-beta-环糊精包合物的制备与表征 |
| 文献子类 | Article |
| 英文摘要 | To optimize the preparation method of the complex of dihydroartemisinin(DHA) included by hydroxypropyl-beta-cyclodextrin(HP-beta-CD),the molar ratio of DHA and HP-beta-CD,inclusion temperature and inclusion time were optimized by the orthogonal design method with the inclusion drug yield and drug loading as the evaluation indexes.The IR spectrum,DSC and PXRD analyses were employed to characterize the complex and the molecular simulation was processed to investigate the tendency of complex formation.The optimized molar ratio of DHA and HP-beta-CD was 1∶5,and the optimized preparation was performed under 50 ℃ for 1 h.The IR spectrum,DSC and PXRD analyses indicated the formation of the complex.The low binding free energy and the high solvent accessible surface obtained by molecular simulation showed that DHA could be included by HP-beta-CD and its solubility could be improved significantly.In conclusion,the optimized conditions for the preparation of DHA-HP-beta-CD complex provide a theoretical and experimental basis for further scale-up research. |
| 资助项目 | 国际科技合作项目[00000000] ; 国家自然科学基金资助项目[00000000] |
| WOS研究方向 | Pharmacology & Pharmacy (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:4504352 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/267861]  |
| 专题 | 药物制剂研究中心 |
| 通讯作者 | Zhang Jiwen |
| 作者单位 | 1.Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, China.; 2.Shanghai Institute of Materia Medica,Chinese Academy of Sciences, Shanghai 201203, China.; 3.Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, China. |
| 推荐引用方式 GB/T 7714 | Chen Fangwei,Guo Tao,Li Haiyan,et al. Preparation and characterization of dihydroartemisinin/hydroxypropyl-beta-cyclodextrin inclusion complex[J]. Acta Pharmaceutica Sinica,2012,47(4):529-534. |
| APA | Chen Fangwei.,Guo Tao.,Li Haiyan.,Guo Zhen.,He Zhonggui.,...&Zhang Jiwen.(2012).Preparation and characterization of dihydroartemisinin/hydroxypropyl-beta-cyclodextrin inclusion complex.Acta Pharmaceutica Sinica,47(4),529-534. |
| MLA | Chen Fangwei,et al."Preparation and characterization of dihydroartemisinin/hydroxypropyl-beta-cyclodextrin inclusion complex".Acta Pharmaceutica Sinica 47.4(2012):529-534. |
入库方式： OAI收割
来源：上海药物研究所
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