Preparation and Pharmacokinetics in Rats of Probucol Solid Dispersions by Hot-melt Extrusion Process
文献类型：期刊论文
| 作者 | Huang Jian1; Gu Wangwen2 ; Jiang Shijun2; Zhang Zhiwen2; Chen Lingli2
|
| 刊名 | Chinese Journal of Pharmaceuticals
 |
| 出版日期 | 2011 |
| 卷号 | 42期号:12页码:902-906 |
| 关键词 | hot-melt extrusion solid dispersion probucol dissolution rate bioavailability |
| ISSN号 | 1001-8255 |
| 其他题名 | 热熔挤出技术制备普罗布考固体分散体及其大鼠体内药动学研究 |
| 文献子类 | Article |
| 英文摘要 | The probucol solid dispersions were prepared with Soluplus as the carrier by hot-melt extrusion process. The equilibrium solubility, dissolution rate and pharmacokinetic behavior in rats of the products were evaluated. The results showed that the cumulative release amount at 30 min from the solid dispersions with the probucol/Soluplus weight ratio of 1:3 was 97%. The results of differential scanning calorimetry and powder X-ray diffraction suggested that probucol dispersed mainly in the molecular state. The results of pharmacokinetics in rats showed that the c_(max) and AUC of probucol solid dispersions were 2.26 times and 2.02 times higher than those of bulk drug, respectively. |
| 资助项目 | 国家重点基础研究发展计划[00000000] |
| WOS研究方向 | Pharmacology & Pharmacy (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:4404444 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/267864]  |
| 专题 | 药物制剂研究中心 |
| 通讯作者 | Gu Wangwen |
| 作者单位 | 1.School of Pharmacy, Jiangsu University, Zhenjiang, Jiangsu 212013, China.; 2.Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. |
| 推荐引用方式 GB/T 7714 | Huang Jian,Gu Wangwen,Jiang Shijun,et al. Preparation and Pharmacokinetics in Rats of Probucol Solid Dispersions by Hot-melt Extrusion Process[J]. Chinese Journal of Pharmaceuticals,2011,42(12):902-906. |
| APA | Huang Jian,Gu Wangwen,Jiang Shijun,Zhang Zhiwen,&Chen Lingli.(2011).Preparation and Pharmacokinetics in Rats of Probucol Solid Dispersions by Hot-melt Extrusion Process.Chinese Journal of Pharmaceuticals,42(12),902-906. |
| MLA | Huang Jian,et al."Preparation and Pharmacokinetics in Rats of Probucol Solid Dispersions by Hot-melt Extrusion Process".Chinese Journal of Pharmaceuticals 42.12(2011):902-906. |
入库方式： OAI收割
来源：上海药物研究所
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