Preparation of Irinotecan Hydrochloride Liposomal Lyophilized Microparticle by Spray-freeze Drying and Its Physico-chemical Characters
文献类型：期刊论文
| 作者 | He Hongliang2; Wang Weiguo2; Gan Yong1 ; Zhang Xinxin1; Guo Yanliang2
|
| 刊名 | China Pharmacy
 |
| 出版日期 | 2010 |
| 卷号 | 21期号:45页码:4274-4278 |
| 关键词 | Irinotecan hydrochloride Liposomal lyophilized microparticles Spray-freeze drying Physico-chemical characters |
| ISSN号 | 1001-0408 |
| 其他题名 | 喷雾冷冻干燥技术制备盐酸伊立替康月旨质体冻干微粒及其理化性质考察 |
| 文献子类 | Article |
| 英文摘要 | OBJECTIVE: To evaluate the feasibility of the preparation of Liposomal lyophilized microparticles by spray-freeze drying (SFD). METHODS: Ammonium sulfate gradient method and SFD were adopted to prepare Irinotecan hydrochloride liposome (CPT-11) and liposomal lyophilized microparticles using irinotecan hydrochloride as active ingredient. Box-Behnken Design (BBD) was used to investigate the effect of the ratio of materials on the encapsulation coefficency of microparticles to optimize SFD using the height of spray nozzle, flow velocity and mass ratio of jet-atomized liquid drop to liquid nitrogen as factors. The physico-chemical characters of prepared liposome and liposomal lyophilized microparticles were analyzed. RESULTS: The optimized SFD technology was as follows: the flow velocity of material was 5.5 mL·min~(-1); the height of spray nozzle was 18.5 cm; the mass ratio of jet-atomized liquid drop to liquid nitrogen was 3.7%. Prepared liposomal lyophilized microparticles were characterized with sound appearance and redispersibility. The particle size, distribution, main component and encapsulation coefficency of liposomal lyophilized microparticles were in line with those of liposome. Liposomal lyophilized microparticles exhibited better stability after 6 month of storage than liposome. CONCLUSION: The liposomal lyophilized microparticles can be prepared by SFD effectively, and the stability of liposome has been improved |
| WOS研究方向 | Pharmacology & Pharmacy (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:4075647 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/267935]  |
| 专题 | 药物制剂研究中心 |
| 作者单位 | 1.Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. 2.School of Bioengineering, He'nan University of Technology, Zhengzhou, Henan 450001, China.; |
| 推荐引用方式 GB/T 7714 | He Hongliang,Wang Weiguo,Gan Yong,et al. Preparation of Irinotecan Hydrochloride Liposomal Lyophilized Microparticle by Spray-freeze Drying and Its Physico-chemical Characters[J]. China Pharmacy,2010,21(45):4274-4278. |
| APA | He Hongliang,Wang Weiguo,Gan Yong,Zhang Xinxin,&Guo Yanliang.(2010).Preparation of Irinotecan Hydrochloride Liposomal Lyophilized Microparticle by Spray-freeze Drying and Its Physico-chemical Characters.China Pharmacy,21(45),4274-4278. |
| MLA | He Hongliang,et al."Preparation of Irinotecan Hydrochloride Liposomal Lyophilized Microparticle by Spray-freeze Drying and Its Physico-chemical Characters".China Pharmacy 21.45(2010):4274-4278. |
入库方式： OAI收割
来源：上海药物研究所
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