Preparation of anethol trithione-phospholipid complex and studies on its pharmacokinetics in rats
文献类型：期刊论文
| 作者 | YAO Ting-ting3; GAN Yong2 ; HAN Si-fei2; ZHU Chun-liu2; HU Shen-ye1; PAN Wei-san3
|
| 刊名 | Journal of Shenyang Pharmaceutical University
 |
| 出版日期 | 2010 |
| 卷号 | 27期号:3页码:168-173 |
| 关键词 | anethol trithione phospholipid complex pharmacokinetics |
| ISSN号 | 1006-2858 |
| 其他题名 | 茴三硫磷脂复合物的制备及其体内外评价 |
| 文献子类 | Article |
| 英文摘要 | Objective To prepare anethol trithione-phospholipid complex and compare the bioavailability and pharmacokinetic characteristics after oral administration of anethol trithione-phospholipid complex and commercial capsules in rats. Methods Digestion in vitro and IR properties of the complex was investigated. The concentration of parent drug and its metabolite after administration of anethol trithione-phospholipid complex and commercial capsules at different time in rats were determined by HPLC. The pharmacokinetic parameters were computed by software program DAS 2.0. Results The IR results proved that the complex was formed.Compared with the commercial capsules, the drug's dissolution was improved and its digestion precipitation rate in vitro was decreased by changing into the phospholide complex. The drug solubility in gastrointestinal tract was remarkably increased by making the preparation. And the capital pharmacokinetic parameters of the complex were changed,the AUC_(0-) of the parent drug and its metabolite of the complex were 1270. 08 and 4001.31mug·h·L~(-1),respectively.Conclusions It is concluded that after oral administration of anethol trithi one-phospholipid complex in rats, the bioavailability of anethol trithione is increased greatly. This is mainly due to an obvious improvement of the oral administration absorption. |
| WOS研究方向 | General & Internal Medicine (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:3836693 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/267954]  |
| 专题 | 药物制剂研究中心 |
| 作者单位 | 1.Shanghai Jiaotong University, Shanghai 200240, China. 2.Shanghai Institute of Materia Medica,Chinese Academic of Sciemces, Shanghai 201203, China.; 3.School of Pharmacy,Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, China.; |
| 推荐引用方式 GB/T 7714 | YAO Ting-ting,GAN Yong,HAN Si-fei,et al. Preparation of anethol trithione-phospholipid complex and studies on its pharmacokinetics in rats[J]. Journal of Shenyang Pharmaceutical University,2010,27(3):168-173. |
| APA | YAO Ting-ting,GAN Yong,HAN Si-fei,ZHU Chun-liu,HU Shen-ye,&PAN Wei-san.(2010).Preparation of anethol trithione-phospholipid complex and studies on its pharmacokinetics in rats.Journal of Shenyang Pharmaceutical University,27(3),168-173. |
| MLA | YAO Ting-ting,et al."Preparation of anethol trithione-phospholipid complex and studies on its pharmacokinetics in rats".Journal of Shenyang Pharmaceutical University 27.3(2010):168-173. |
入库方式： OAI收割
来源：上海药物研究所
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