Multidimensional spatial triangular area as an index for the evaluation of the release-absorption correlation of multiple component traditional Chinese medicines
文献类型：期刊论文
| 作者 | Li Haiyan2 ; Gu Jingkai1; Guo Zhen2; Shi Senlin3; Zhang Jiwen2
|
| 刊名 | Acta Pharmaceutica Sinica
 |
| 出版日期 | 2010 |
| 卷号 | 45期号:7页码:895-900 |
| 关键词 | traditional Chinese medicine multiple components release multiple components absorption in vitro-in vivo correlation |
| ISSN号 | 0513-4870 |
| 其他题名 | 多维空间三角形面积法研究中药多组分释放-吸收相关性的思路与方法 |
| 文献子类 | Article |
| 英文摘要 | The paper is aimed to provide a novel index, named as multidimensional spatial triangular area, for the evaluation of the release-absorption correlation of multiple component traditional Chinese medicines (TCMs). The applicability of the method was demonstrated by the example data. The method and standard practice for evaluation of the release-absorption correlation for western medicines with single compound could not be applied to TCMs with multiple components. The release percentage or absorption percentage of the multiple components for TCMs at the sampling time was a point in the multidimensional space. The area of the triangle formed by the sequential three points represented the changing characteristics of the components' release and absorption kinetics. The side lengths of the triangle could be calculated from the spatial distances between each two of the sequential three points. Then the triangle area could be obtained by the side lengths. The in vitro release-in vivo absorption correlation of the multiple components could be represented by the correlation between the integrating values of the release triangle areas and that of the absorption triangle areas. The results of the examples indicated that the multidimensional spatial triangular area method could treat the multiple components in a holistic way, in line with the holism of the TCMs. Therefore, the multidimensional spatial triangular area method provided new methodology for the release-absorption correlation of the TCMs with multiple components |
| 资助项目 | 国家科技支撑计划项目[00000000] ; 中国科学院知识创新工程重要方向项目[00000000] ; 上海市科委科研计划项目[00000000] ; 国家科技重大专项课题[00000000] |
| WOS研究方向 | Pharmacology & Pharmacy (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:3908244 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/267966]  |
| 专题 | 药物制剂研究中心 |
| 通讯作者 | Zhang Jiwen |
| 作者单位 | 1.Jilin University, Changchun, Jilin 130021, China.; 2.Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.; 3.Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, China. |
| 推荐引用方式 GB/T 7714 | Li Haiyan,Gu Jingkai,Guo Zhen,et al. Multidimensional spatial triangular area as an index for the evaluation of the release-absorption correlation of multiple component traditional Chinese medicines[J]. Acta Pharmaceutica Sinica,2010,45(7):895-900. |
| APA | Li Haiyan,Gu Jingkai,Guo Zhen,Shi Senlin,&Zhang Jiwen.(2010).Multidimensional spatial triangular area as an index for the evaluation of the release-absorption correlation of multiple component traditional Chinese medicines.Acta Pharmaceutica Sinica,45(7),895-900. |
| MLA | Li Haiyan,et al."Multidimensional spatial triangular area as an index for the evaluation of the release-absorption correlation of multiple component traditional Chinese medicines".Acta Pharmaceutica Sinica 45.7(2010):895-900. |
入库方式： OAI收割
来源：上海药物研究所
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