Preparation and Quality Evaluation of Alprostadil Solid Lipid Nanoparticles
文献类型：期刊论文
| 作者 | ZOU Jiang-fu1; GU Wang-wen2 ; LI Ya-ping1; CHEN Ling-li2
|
| 刊名 | Chinese Journal of Pharmaceuticals
 |
| 出版日期 | 2009 |
| 卷号 | 40期号:7页码:495-499 |
| 关键词 | alprostadil solid lipid nanoparticles film dispersing method lyophilization entrapment efficiency |
| ISSN号 | 1001-8255 |
| 其他题名 | 前列地尔固体脂质纳米粒的制备及质量评价 |
| 文献子类 | Article |
| 英文摘要 | The alprostadil solid lipid nanoparticles (SLN) were prepared by film dispersing method and followed by high pressure homogenization and lyophilization. The mean particle size of the alprostadil SLN was (137.2 7.7) nm and the entrapment efficiency was above 90%. The in vitro release test showed that accumulative release at 24 h was 43.6% in phosphate buffer (pH 7.4) and the release curve was fitted with Weibull equation. No significant changes were measured after the alprostadil SLN were stored at (42) ℃ and (252) ℃ for six monthes. |
| WOS研究方向 | Pharmacology & Pharmacy (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:3514645 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/267978]  |
| 专题 | 药物制剂研究中心 |
| 通讯作者 | CHEN Ling-li |
| 作者单位 | 1.School of Pharmacy, Jiangsu University, Zhenjiang, Jiangsu 212013, China.; 2.Center for Drug Delivery System, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. |
| 推荐引用方式 GB/T 7714 | ZOU Jiang-fu,GU Wang-wen,LI Ya-ping,et al. Preparation and Quality Evaluation of Alprostadil Solid Lipid Nanoparticles[J]. Chinese Journal of Pharmaceuticals,2009,40(7):495-499. |
| APA | ZOU Jiang-fu,GU Wang-wen,LI Ya-ping,&CHEN Ling-li.(2009).Preparation and Quality Evaluation of Alprostadil Solid Lipid Nanoparticles.Chinese Journal of Pharmaceuticals,40(7),495-499. |
| MLA | ZOU Jiang-fu,et al."Preparation and Quality Evaluation of Alprostadil Solid Lipid Nanoparticles".Chinese Journal of Pharmaceuticals 40.7(2009):495-499. |
入库方式： OAI收割
来源：上海药物研究所
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