Preparation and Evaluation in vivo and in vitro of Clenbuterol Hydrochloride Sustained-release Bilayer Tablets
文献类型：期刊论文
| 作者 | DING Sheng2; ZHANG Hongji2; GU Wangwen1 ; CHEN Lingli1; LI Yaping1
|
| 刊名 | Chinese Journal of Modern Applied Pharmacy
 |
| 出版日期 | 2009 |
| 卷号 | 26期号:1页码:46-49 |
| 关键词 | clenbuterol Hydrochloride sustained-release bilayer tablets in vitro and in vivo correlation |
| ISSN号 | 1007-7693 |
| 其他题名 | 盐酸克仑特罗双层缓释片的研制及体内外评价 |
| 文献子类 | Article |
| 英文摘要 | OBJECTIVE To prepare clenbuterol hydrochloride sustained-release bilayer tablets and study its pharmaceutical characteristics in vivo and in vitro. METHODS HPMC and EC mixed matrix were used to prepare clenbuterol hydrochloride sustained-release bilayer tablets by direct compression technique and wet granulation technique. The release characteristics in vitro and phmcokinetics in dogs of clenbuterol hydrochloride sustained-release bilayer tablets were investigated. RESULTS The drug dissolution of sustained-release bilayer tablets was consistent with Higuchi equation. The peak levels ( C_(max)) after administration of sustained-release bilayer tablets and reference tablets were (5. 86 0.33) and ( 11.430. 64) ng·mL~(-1) at (3. 170.73) and (2.020.35) h, respectively. The mean elimination half lives ( t_(1/2)) were found to be ( 11.901.42) and (6. 180.81 ) h,respectively. AUC_(0-4) were calculated to be (65.08 2.63 ) and ( 68.002. 89 ) ng ·h·. ML~(-1), respectively. CONCLUSION The clenbuterol hydrochloride sustained-release bilayer tablets exhibited both sustained-and rapid-release characteristics in vitro. The calculated MRT of sustained-release bilayer tablets was significantly more than that of reference tablets. There existed correlation between the in vitro release and in vivo absorption. |
| WOS研究方向 | Pharmacology & Pharmacy (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:3514068 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/267984]  |
| 专题 | 药物制剂研究中心 |
| 通讯作者 | GU Wangwen |
| 作者单位 | 1.Shanghai Institute of Materia Medica Chinese Academy of Sciences, Shanghai 201203, China. 2.School of Pharmacy,Jiangsu University, Zhenjiang, Jiangsu 212013, China.; |
| 推荐引用方式 GB/T 7714 | DING Sheng,ZHANG Hongji,GU Wangwen,et al. Preparation and Evaluation in vivo and in vitro of Clenbuterol Hydrochloride Sustained-release Bilayer Tablets[J]. Chinese Journal of Modern Applied Pharmacy,2009,26(1):46-49. |
| APA | DING Sheng,ZHANG Hongji,GU Wangwen,CHEN Lingli,&LI Yaping.(2009).Preparation and Evaluation in vivo and in vitro of Clenbuterol Hydrochloride Sustained-release Bilayer Tablets.Chinese Journal of Modern Applied Pharmacy,26(1),46-49. |
| MLA | DING Sheng,et al."Preparation and Evaluation in vivo and in vitro of Clenbuterol Hydrochloride Sustained-release Bilayer Tablets".Chinese Journal of Modern Applied Pharmacy 26.1(2009):46-49. |
入库方式： OAI收割
来源：上海药物研究所
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