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Stability of materiomic release kinetics of Yinqiaojiedu tablets and its synchronicity evaluation with visualization method

文献类型：期刊论文

作者FU Dan-dan2; LING Die2; CHEN Li-bing2; SHI Ting-ting1; GE Wei-hong1; SHI Sen-lin1; ZHANG Ji-wen2
刊名Journal of China Pharmaceutical University
出版日期2009
卷号40期号:2页码:125-130
关键词materiome of TCM release kinetics synchronicity of release kinetics stability Yinqiaojiedu tablets
ISSN号1000-5048
其他题名银翘解毒片物质组释放动力学稳定性及释放同步性的可视化评价
文献子类Article
英文摘要Aim: To investigate the materiomic release kinetic characteristics and synchronicity of Yinqiaojiedu tablets with strengthen temperature, humidity and illumination. Methods: The Yirtqiaojiedu tablets, totally 11 groups of samples, were processed as single factor test of the temperatures (60 ℃ and 80℃), relative humidity　(75% and 90% ) and illumination (4 500 LX), for which the materiomic release kinetics were tested at 0, 5, and 10 day using the paddle method defined by Chinese Pharmacopoeia at a rotation rate of 50 r/min. The UV spectra of the dissolution samples were compared with the standard materiomie compositional spectrum by Kalman filter method to calculate the materiome release rates and the release profiles. The numeric materiome release data were transformed into colors by MatLab~(R) to visualize the materiomic release profiles and synchronicity. Results: High temperature significantly reduced the materiomic release rates of Yinqiaojicdu tablets, while high humidity accelerated the release rates of the samples slightly. Illumination had no obvious effect on the materiomic release kinetics of Yinqiaojiedu tablets, The in vitro materiomic release kinetics of Yinqhtojiedu tablets were well fitted with the first-order equatinns. Conclusion: High temperature and high humidity are the major factors to the materiomic release kinetics of Yinqiaojiedu tablets.
资助项目国家自然科学基金[00000000] ; 中国科学院上海药物研究所基础研究项目[00000000]
WOS研究方向Pharmacology & Pharmacy (provided by Clarivate Analytics)
语种中文
CSCD记录号CSCD:3542901
源URL[http://119.78.100.183/handle/2S10ELR8/267994]  
专题药物制剂研究中心
通讯作者ZHANG Ji-wen
作者单位1.School of Pharmacy, Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, China.
2.Center for Drug Delivery System, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.;
推荐引用方式
GB/T 7714		 FU Dan-dan,LING Die,CHEN Li-bing,et al. Stability of materiomic release kinetics of Yinqiaojiedu tablets and its synchronicity evaluation with visualization method[J]. Journal of China Pharmaceutical University,2009,40(2):125-130.
APA FU Dan-dan.,LING Die.,CHEN Li-bing.,SHI Ting-ting.,GE Wei-hong.,...&ZHANG Ji-wen.(2009).Stability of materiomic release kinetics of Yinqiaojiedu tablets and its synchronicity evaluation with visualization method.Journal of China Pharmaceutical University,40(2),125-130.
MLA FU Dan-dan,et al."Stability of materiomic release kinetics of Yinqiaojiedu tablets and its synchronicity evaluation with visualization method".Journal of China Pharmaceutical University 40.2(2009):125-130.

入库方式： OAI收割

来源：上海药物研究所

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