Ocular pharmacokinetics of dexamethasone cubosomes in rabbit aqueous humor
文献类型：期刊论文
| 作者 | GAN Li2; GAN Yong1 ; SHEN Jin-qiu2; ZHU Jia-bi2
|
| 刊名 | Journal of China Pharmaceutical University
 |
| 出版日期 | 2009 |
| 卷号 | 40期号:4页码:327-331 |
| 关键词 | dexamethasone cubosomes microdialysis aqueous humor pharmacokinetics |
| ISSN号 | 1000-5048 |
| 其他题名 | 地塞米松纳米立方液晶眼用制剂家兔房水药代动力学 |
| 文献子类 | Article |
| 英文摘要 | Aim: To prepare novel cubosome system for effective ocular drug delivery with dexamethasone(DEX) as model drug, and investigate its pharmacokinetic profile in rabbit aqueous humor. Methods: DEX cubosomes was prepared by the method of high-pressure homogenization, and its particle size was determined by the laser particle sizer, and the microstructure observed by cryo-TEM. In addition, Draize method was used to evaluate the ocular irritation of DEX cubosomes. Finally, aqueous humor microdialysis was utilized to evaluate its pharmacokinetics in rabbits. Results: Average diameter of DEX cubosomes was about 200 nm, and the cubic structure of the particles was evident under the cryo-TEM. It was indicated by Draize scores that this dosage form exhibited excellent ocular tolerance. Results of pharmacokinetic profiles in aqueous humor showed that AUC_(0240) and c_(max) of the rabbit group administered with DEX cubosomes were significantly higher than those of the control group( DEX sodium phosphate eye drops), with AUC_(0240) of the formulation Fl( 10% oil content) and F2(20% oil content) is being about 1. 8 and 2. 9 times higher than those of the control group, respectively( P <0. 05). Conclusion: The novel ocular drug delivery system of DEX cubosomes was capable of increasing significantly the drug concentration in aqueous humor, and improving the ocular bioavailability. |
| WOS研究方向 | Pharmacology & Pharmacy (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:3739696 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/267997]  |
| 专题 | 药物制剂研究中心 |
| 作者单位 | 1.Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. 2.Institute of Pharmaceutics, China Pharmaceutical University, Nanjing, Jiangsu 210009, China.; |
| 推荐引用方式 GB/T 7714 | GAN Li,GAN Yong,SHEN Jin-qiu,et al. Ocular pharmacokinetics of dexamethasone cubosomes in rabbit aqueous humor[J]. Journal of China Pharmaceutical University,2009,40(4):327-331. |
| APA | GAN Li,GAN Yong,SHEN Jin-qiu,&ZHU Jia-bi.(2009).Ocular pharmacokinetics of dexamethasone cubosomes in rabbit aqueous humor.Journal of China Pharmaceutical University,40(4),327-331. |
| MLA | GAN Li,et al."Ocular pharmacokinetics of dexamethasone cubosomes in rabbit aqueous humor".Journal of China Pharmaceutical University 40.4(2009):327-331. |
入库方式： OAI收割
来源：上海药物研究所
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