Preparation and in vitro evaluation of thermo-and ion-sensitive in situ gels of vibavirin via intranasal administration
文献类型：期刊论文
| 作者 | LUAN Lin1; GAN Yong2 ; ZHANG Xin-xin1; WANG Chang-guang1; LIU Qiang1; PAN Wei-san1
|
| 刊名 | Journal of Shenyang Pharmaceutical University
 |
| 出版日期 | 2009 |
| 卷号 | 26期号:4页码:249 |
| 关键词 | deacetylated gellan gum poloxamer 407 thermo-ion-sensitive mixed in situ gels ribavirin nasal administration gels |
| ISSN号 | 1006-2858 |
| 其他题名 | 利巴韦林温度-离子敏感型鼻用原位凝胶喷雾剂的制备及体外性质考察 |
| 文献子类 | Article |
| 英文摘要 | Objective To prepare thermo-ion-sensitive in situ gels of vibavirin, which possess favorable phase transition temperature,phase transition cationic intensity,spray particle size and sustained-release properties.Methods Concentrations of deacetylated gellan gum and poloxamer 407 in the in situ gel were decided by investigating the phase transition temperature, phase transition cationic intensity and spray particle size.The amount of drained water after gels gelated,gels corrosion rate,in vitro vibavirin release profile and mucoadhesive properties were evaluated.Results The in situ gel was prepared with 0.3% (w)deacetylated gellan gum and 18.0% (w) poloxamer 407, with phase transition temperature of 32.6 ℃, phase transition cationic intensity of 93.4 mmol·kg~(-1), spray particle size of 68mum,the amount of drained water after gels gelated of (13.8 0.8) %, gel corrosion rate of 1.0*10~(-4), deformation to failure of (1.60 0.06) mm.Meanwhile, the drug release profile of this in situ gel was favorable.Conclusions The in situ gel with 0.3% (w)deacetylated gellan gum and 18.0% (w)poloxamer 407 might be a suitable nasal delivery system for sustained-release of hydrophilic drugs. |
| WOS研究方向 | Pharmacology & Pharmacy (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:3540075 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/268011]  |
| 专题 | 药物制剂研究中心 |
| 作者单位 | 1.School of Pharmacy,Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, China.; 2.Shanghai Institute of Materia Medica,Chinese Academy of Sciences, Shanghai 201203, China. |
| 推荐引用方式 GB/T 7714 | LUAN Lin,GAN Yong,ZHANG Xin-xin,et al. Preparation and in vitro evaluation of thermo-and ion-sensitive in situ gels of vibavirin via intranasal administration[J]. Journal of Shenyang Pharmaceutical University,2009,26(4):249. |
| APA | LUAN Lin,GAN Yong,ZHANG Xin-xin,WANG Chang-guang,LIU Qiang,&PAN Wei-san.(2009).Preparation and in vitro evaluation of thermo-and ion-sensitive in situ gels of vibavirin via intranasal administration.Journal of Shenyang Pharmaceutical University,26(4),249. |
| MLA | LUAN Lin,et al."Preparation and in vitro evaluation of thermo-and ion-sensitive in situ gels of vibavirin via intranasal administration".Journal of Shenyang Pharmaceutical University 26.4(2009):249. |
入库方式： OAI收割
来源：上海药物研究所
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