Preparation and Quality Evaluation of Docetaxel Lyophilized Liposomes
文献类型：期刊论文
| 作者 | ZHANG Hongji1; DING Sheng1; GU Wangwen2 ; LI Yaping2; CHEN Lingli2
|
| 刊名 | Chinese Journal of Pharmaceuticals
 |
| 出版日期 | 2008 |
| 卷号 | 39期号:2页码:113-116 |
| 关键词 | docetaxel liposome film dispersion method lyophilization encapsulation efficiency release in vitro |
| ISSN号 | 1001-8255 |
| 其他题名 | 多西他赛脂质体冻干粉的制备及质量评价 |
| 文献子类 | Article |
| 英文摘要 | Docetaxel liposomes were prepared by film dispersion method and followed by lyophilization. Orthogonal design was adopted to optimize the formulation using encapsulation efficiency as the evaluation parameter. The appearance, size and the distribution, encapsulation efficiency, in vitro release and stability of the products were investigated. The results showed that the dispersed docetaxel lyophilized liposomes were spherical with the mean diameter of （167.171.2） nm and the mean encapsulation efficiency of （85.90.6） %. The average accumulative release of docetaxel liposomes in vitro was 70.3 % at 24h and the release curve was fitted with Weibull equation. No significant change was found when docetaxel lyophilized liposomes were stored at 4℃ for 3 months. |
| WOS研究方向 | Pharmacology & Pharmacy (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:3211658 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/268038]  |
| 专题 | 药物制剂研究中心 |
| 作者单位 | 1.School of Pharmacy, Jiangsu University, Zhenjiang, Jiangsu 212013, China.; 2.Center for Drug Delivery System, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. |
| 推荐引用方式 GB/T 7714 | ZHANG Hongji,DING Sheng,GU Wangwen,et al. Preparation and Quality Evaluation of Docetaxel Lyophilized Liposomes[J]. Chinese Journal of Pharmaceuticals,2008,39(2):113-116. |
| APA | ZHANG Hongji,DING Sheng,GU Wangwen,LI Yaping,&CHEN Lingli.(2008).Preparation and Quality Evaluation of Docetaxel Lyophilized Liposomes.Chinese Journal of Pharmaceuticals,39(2),113-116. |
| MLA | ZHANG Hongji,et al."Preparation and Quality Evaluation of Docetaxel Lyophilized Liposomes".Chinese Journal of Pharmaceuticals 39.2(2008):113-116. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。