Preparation and in vitro Release of Verapamil Hydrochloride Pulsatile Release Tablets
文献类型：期刊论文
| 作者 | YU Feiqian1; GAN Yong3 ; ZHU Chunliu3; ZHANG Xinxin1; PAN Weisan1
|
| 刊名 | Chinese Journal of Pharmaceuticals
 |
| 出版日期 | 2008 |
| 卷号 | 39期号:6页码:423-427 |
| 关键词 | verapamil hydrochloride osmotic pump pulsatile release lag time pH-independent |
| ISSN号 | 1001-8255 |
| 其他题名 | 盐酸维拉帕米脉冲控释片的制备及体外释放度研究 |
| 文献子类 | Article |
| 英文摘要 | The osmotic pump controlled-release verapamil hydrochloride tablets were coated with the inner coating layer(lag time) and outer coating layer (controlled-release) to prepare the pulsatile release tablets. The effects of coating thickness of the two layers and the formulation of the outer layer on lag time and release rate were investigated. The in vitro release behaviors of the products in different pH value media were also investigated. The results indicated that there was a linear correlation between the inner layer weight and lag time (r=0.9959). The thickness of the inner layer did not signifi cantly affect drug release rate. The kinds and amount of pore-making agent and the thickness of the outer layer also affected drug release. Although the number of delivery orifi ce had rarely in? uence on drug release, less orifi ce would result in the expansion of tablets. Furthermore, the lag time and release rate were pH-independent. |
| WOS研究方向 | Pharmacology & Pharmacy (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:3304198 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/268041]  |
| 专题 | 药物制剂研究中心 |
| 作者单位 | 1.School of Pharmacy; 2.Shanghai 201203, China. 3.Shanghai Institute of Materia Medica; 4.Shenyang, Liaoning 110016, China.; |
| 推荐引用方式 GB/T 7714 | YU Feiqian,GAN Yong,ZHU Chunliu,et al. Preparation and in vitro Release of Verapamil Hydrochloride Pulsatile Release Tablets[J]. Chinese Journal of Pharmaceuticals,2008,39(6):423-427. |
| APA | YU Feiqian,GAN Yong,ZHU Chunliu,ZHANG Xinxin,&PAN Weisan.(2008).Preparation and in vitro Release of Verapamil Hydrochloride Pulsatile Release Tablets.Chinese Journal of Pharmaceuticals,39(6),423-427. |
| MLA | YU Feiqian,et al."Preparation and in vitro Release of Verapamil Hydrochloride Pulsatile Release Tablets".Chinese Journal of Pharmaceuticals 39.6(2008):423-427. |
入库方式： OAI收割
来源：上海药物研究所
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