Novel evaluation theories of kinetics for controlled-release drug delivery systems
文献类型：期刊论文
| 作者 | ZHANG Jiwen1 ; CHEN Jun3; GAO Meihua3; CHEN Libing2
|
| 刊名 | Journal of China Pharmaceutical University
 |
| 出版日期 | 2008 |
| 卷号 | 39期号:1页码:28-31 |
| 关键词 | controlled-release drug delivery systems release kinetics felodipine osmotic pump tablets |
| ISSN号 | 1000-5048 |
| 其他题名 | 控释制剂释放动力学评价理论研究 |
| 文献子类 | Article |
| 英文摘要 | Aim：To study the theory and kinetic modeling for the release characteristics of the controlled-release drug delivery systems. MethodS：On the basis of the zero-order release kinetics, the principles and models were established focusing on the characteristics of the release profile and its differential function. The controlled-release kinetics of felodipine osmotic drug delivery systems were assessed using this method as an illustration. Results： The including index of controlled release （ICR）, index for release difference of the initial phase （IRDi） and index for release difference of the terminal phase （IRDt）, were established. The results indicated their utility in the quantification of the release difference of the felodipine osmotic drug delivery system as a function of the rotation speeds. ICRs approached 70, 8%, The new approach is 74.8%, and 64.2% at the rotation speed of 75,100 and 150 r/min, respectively. Conclusion： effective in the evaluation of the release kinetics of different release phases as well as a whole profile in the quantitative design of the controlled-release drug delivery systems. |
| 资助项目 | 国家高技术研究发展计划（八六三计划）资助项目（No.2006AA02Z336）[00000000] ; 中国科学院上海药物研究所新药基础研究资助项目（07G603F015）[00000000] |
| WOS研究方向 | Pharmacology & Pharmacy (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:3206450 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/268067]  |
| 专题 | 药物制剂研究中心 |
| 通讯作者 | ZHANG Jiwen |
| 作者单位 | 1.Center for Drug Delivery Systems, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.; 2.College of Medical, Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, China. 3.Hefei Lifang Pharmaceutical Ltd Co, Hefei, Anhui 230088, China.; |
| 推荐引用方式 GB/T 7714 | ZHANG Jiwen,CHEN Jun,GAO Meihua,et al. Novel evaluation theories of kinetics for controlled-release drug delivery systems[J]. Journal of China Pharmaceutical University,2008,39(1):28-31. |
| APA | ZHANG Jiwen,CHEN Jun,GAO Meihua,&CHEN Libing.(2008).Novel evaluation theories of kinetics for controlled-release drug delivery systems.Journal of China Pharmaceutical University,39(1),28-31. |
| MLA | ZHANG Jiwen,et al."Novel evaluation theories of kinetics for controlled-release drug delivery systems".Journal of China Pharmaceutical University 39.1(2008):28-31. |
入库方式： OAI收割
来源：上海药物研究所
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