Preparation of PEG-modified nanostructured lipid carriers loaded with hydroxycamptothecin and tissue distribution in mice
文献类型：期刊论文
| 作者 | ZHANG Xinxin2 ; GAN Yong1; YANG Xinggang2; ZHU Chunliu1; GAN Li1; NIE Shufang2; PAN Weisan2
|
| 刊名 | Acta Pharmaceutica Sinica
 |
| 出版日期 | 2008 |
| 卷号 | 43期号:1页码:91-96 |
| 关键词 | hydroxycamptothecin nanostructured lipid carrier tissue distribution lung targeting |
| ISSN号 | 0513-4870 |
| 其他题名 | 聚乙二醇修饰的羟基喜树碱纳米脂质载体的制备及其小鼠组织分布 |
| 文献子类 | Article |
| 英文摘要 | Hydroxycamptothecin(HCPT) loaded PEG modified nanostructured lipid carriers(HCPT-PEG-NLC) and nanostructured lipid carriers(HCPT-NLC) were prepared by melt emulsification and homogenization method.The morphology,particle size and encapsulation efficiency of them were investigated.HCPT concentrations in plasma,heart,liver,spleen,lung,kidney and ovary were determined after iv of HCPT injection,HCPT-PEG-NLC and HCPT-NLC in mice.The targeting indexes of HCPT-PEG-NLC and HCPT-NLC were calculated.The transmission electron microscope imaging showed that HCPT-PEG-NLC and HCPT-NLC exhibited a spherical shape.The particle sizes of them were((88.6)22.5) and(127.243.4) nm.The encapsulation efficiency were(90.513.29)% and(84.372.81)%,respectively.After iv injection into the tail vein of mice,HCPT plasma concentrations of HCPT-PEG-NLC and HCPT-NLC were higher than that of HCPT injection at each sampling time.They also showed longer elimination time in every tissue.HCPT-NLC accumulated in endothelial system(RES),R_e and C_e of it in liver and spleen were significantly higher than HCPTPEG-NLC.HPCT-PEG-NLC prolonged circulation time and increased bioavailability of HCPT.MRT and AUC_(0-24 h) of it were 19.80 and 17.02 times higher than those of HCPT injection.It also significantly reduced phagocytosis of RES,and showed lung targeting effect(R_e and C_e were 14.51 and 41.35).To summarize,HCPT-PEG-NLC could prolong the circulation time of HCPT in vivo,and had the lung targeting effect.It was a promising carrier to increase therapeutic effect of HCPT in treating lung cancer. |
| 资助项目 | 国家自然基金资助项目（30740060）[00000000] |
| WOS研究方向 | Pharmacology & Pharmacy (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:3206676 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/268087]  |
| 专题 | 药物制剂研究中心 |
| 作者单位 | 1.Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. 2.School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, China.; |
| 推荐引用方式 GB/T 7714 | ZHANG Xinxin,GAN Yong,YANG Xinggang,et al. Preparation of PEG-modified nanostructured lipid carriers loaded with hydroxycamptothecin and tissue distribution in mice[J]. Acta Pharmaceutica Sinica,2008,43(1):91-96. |
| APA | ZHANG Xinxin.,GAN Yong.,YANG Xinggang.,ZHU Chunliu.,GAN Li.,...&PAN Weisan.(2008).Preparation of PEG-modified nanostructured lipid carriers loaded with hydroxycamptothecin and tissue distribution in mice.Acta Pharmaceutica Sinica,43(1),91-96. |
| MLA | ZHANG Xinxin,et al."Preparation of PEG-modified nanostructured lipid carriers loaded with hydroxycamptothecin and tissue distribution in mice".Acta Pharmaceutica Sinica 43.1(2008):91-96. |
入库方式： OAI收割
来源：上海药物研究所
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