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Novel method for the evaluation of the synchronicity of the chemomic release/dissolution of multi-component traditional Chinese medicines
文献类型：期刊论文
| 作者 | ZHANG Jiwen2 ; CHEN Libing1; GU Jingkai3; GE Weihong1
|
| 刊名 | Acta Pharmaceutica Sinica
 |
| 出版日期 | 2008 |
| 卷号 | 43期号:6页码:647-651 |
| 关键词 | 释放同步性 化合物组 Kalman滤波法 多组分中药 化合物组相对误差 同步性因子 |
| ISSN号 | 0513-4870 |
| 其他题名 | 多组分中药化合物组释放同步性评价方法 |
| 文献子类 | Article |
| 英文摘要 | Due to the diversity of components within the traditional Chinese medicines （TCMs）, the release profiles of the components in the TCM dosage forms vary dramatically and no quantification method is available to determine the variance yet. Based upon the principles of Kalman filter method, the authors defined a new parameter, relative chemomic error （epsilon）, to evaluate the asynchronous nature of the components in TCMs, and a derivative parameter as synchronization factor （SF） to quantify the synchronicity of the chemome of the TCMs. The average synchronization factor （ SF_(av) ） was accordingly derived to simultaneously quantify the release/dissolution profiles of the multi-components in TCMs. Randomly generated simulation data were processed to demonstrate the chemomic data processing and the methodology. The results indicated that the novel parameter epsilon was well correlated （r = 0. 996 8） with the coefficient of variation from the conventional release profiles of all the components. As the asynchronicity was the intrinsic characteristics of the multi-component TCMs, the synchronicity might be a new target of quality control of TCMs. The methods established by this report can be used a quantitative tool for the evaluation of the chemomic release synchronization of TCMs. |
| 资助项目 | 国家高技术研究发展计划（863计划）资助项目（2006AA02Z336）[00000000] ; 国家科技支撑计划项目（2006BAI098B08-08）[00000000] ; 中国科学院上海药物研究所新药基础研究项目资助（07G603F015）[00000000] |
| WOS研究方向 | Pharmacology & Pharmacy (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:3295598 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/268094]  |
| 专题 | 药物制剂研究中心 |
| 通讯作者 | ZHANG Jiwen |
| 作者单位 | 1.Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, China.; 2.Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.; 3.Jilin University, Changchun, Jilin 130021, China. |
| 推荐引用方式 GB/T 7714 | ZHANG Jiwen,CHEN Libing,GU Jingkai,et al. Novel method for the evaluation of the synchronicity of the chemomic release/dissolution of multi-component traditional Chinese medicines[J]. Acta Pharmaceutica Sinica,2008,43(6):647-651. |
| APA | ZHANG Jiwen,CHEN Libing,GU Jingkai,&GE Weihong.(2008).Novel method for the evaluation of the synchronicity of the chemomic release/dissolution of multi-component traditional Chinese medicines.Acta Pharmaceutica Sinica,43(6),647-651. |
| MLA | ZHANG Jiwen,et al."Novel method for the evaluation of the synchronicity of the chemomic release/dissolution of multi-component traditional Chinese medicines".Acta Pharmaceutica Sinica 43.6(2008):647-651. |
入库方式： OAI收割
来源：上海药物研究所
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