Application of the theories of materiomic release kinetics to the evaluation of the sustained release kinetics and synchronicity of Yinqiaojiedu honeyed pills
文献类型：期刊论文
| 作者 | LING Die3; ZHANG Jiwen3 ; CHEN Libing1; LIN Meng1; GE Weihong1; GU Jingkai2
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| 刊名 | Acta Pharmaceutica Sinica
 |
| 出版日期 | 2008 |
| 卷号 | 43期号:11页码:1140-1146 |
| 关键词 | materiome of TCM release kinetics Yinqiaojiedu honeyed pill prototype of sustained-release dosage forms of TCM synchronicity of release kinetics |
| ISSN号 | 0513-4870 |
| 其他题名 | 应用中药物质组释放动力学理论研究银翘解毒丸的缓释动力学及其同步性 |
| 文献子类 | Article |
| 英文摘要 | Yinqiaojiedu honeyed pills were equally divided into 1/4, 1.8, 1/12, and 1/16 parts. The materiomics release rates within 12 h of the intact Yinqiaojiedu honeyed pills and the divided granules were determined by the paddle method with a rotate speed at 100 r · min^-1 and the materiome was quantified by UV-scan and Kalman filter methods. The intact Yinqiaojiedu honeyed pills behaved typical sustained release profiles, while the well-divided portions also maintained a sustained release profile over 2 -4 h. The release rates were well correlated with the extents for the divisions of the pills. The Weibull distribution parameters, Td and T50, were reduced in line with the particle size, indicating that the ways of administration of the pills may play a role in the in vivo pharmacokinetics of the pills. The visualization results showed obvious difference of materiomic release synchronicities between the intact pills and the equally divided particles, and the divisions enhanced the asynchronization. Therefore the novel theory of materiomic release/dissolution kinetics of traditional Chinese medicines （TCMs） quantitatively proved the traditional dosage form, namely, honeyed pills, as a prototype of the sustained-release dosage form with a visualization of the scientific connotation to the old saying in the classics of TCM, Pills, the moderate ones in action （丸者缓也）. In terms of materiome increase for each period of the release profiles, the materiomic release synchronicity was visually demonstrated. The novel theories provided methodological basis for the evaluation of traditional dosage forms and the design of the modern drug delivery systems for TCMs. |
| 资助项目 | 国家高级技术研究发展计划（863计划）资助项目（2006AA022336）[00000000] ; 国家科技支撑计划项目（2006BA1098808-08）[00000000] ; 中国科学院上海药物研究所新药团队基础研究项目（07G603F015）[00000000] |
| WOS研究方向 | Pharmacology & Pharmacy (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:3475746 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/268098]  |
| 专题 | 药物制剂研究中心 |
| 作者单位 | 1.College of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, China.; 2.Research Center for Drug Metabolism, Jilin University, Changchun, Jilin 130021, China. 3.Center for Drug Delivery System, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.; |
| 推荐引用方式 GB/T 7714 | LING Die,ZHANG Jiwen,CHEN Libing,et al. Application of the theories of materiomic release kinetics to the evaluation of the sustained release kinetics and synchronicity of Yinqiaojiedu honeyed pills[J]. Acta Pharmaceutica Sinica,2008,43(11):1140-1146. |
| APA | LING Die,ZHANG Jiwen,CHEN Libing,LIN Meng,GE Weihong,&GU Jingkai.(2008).Application of the theories of materiomic release kinetics to the evaluation of the sustained release kinetics and synchronicity of Yinqiaojiedu honeyed pills.Acta Pharmaceutica Sinica,43(11),1140-1146. |
| MLA | LING Die,et al."Application of the theories of materiomic release kinetics to the evaluation of the sustained release kinetics and synchronicity of Yinqiaojiedu honeyed pills".Acta Pharmaceutica Sinica 43.11(2008):1140-1146. |
入库方式： OAI收割
来源：上海药物研究所
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