Optimization and evaluation of a new antischistosomal drug QH917 self-microemulsifying drug delivery system
文献类型：期刊论文
| 作者 | ZHANG Jianyuan2; GAN Yong1 ; GAN Li1; ZHU Chunliu1; PAN Weisan2
|
| 刊名 | Acta Pharmaceutica Sinica
 |
| 出版日期 | 2007 |
| 卷号 | 42期号:4页码:434-439 |
| 关键词 | antischistosomal drug central composite design-response surface methodology selfmicroemulsifying drug delivery system in situ intestinal absorption |
| ISSN号 | 0513-4870 |
| 其他题名 | 新型抗血吸虫药物QH917自微乳化释药系统的优化和评价 |
| 文献子类 | Article |
| 英文摘要 | To screen a new poorly water-soluble antischistosomal drug QH917 self-microemulsifying drug delivery system which has steady release in vitro and absorption in situ separately.The formulation was optimized using central composite design-response surface methodology.Independent variables were oil content(%) and the weight ratio of surfactant and cosurfactant(K_m),while response variables were self-microemulsifying time(t),mean particle size(PS) and polydispersity index(PI).The effects of ionic strength,food,pH,rotation speed and medium volume on drug release of the optimized formulation were evaluated under conditions simulating in vivo physiological situations.The absorption of the optimized formulation was studied using in situ intestinal permeability technique of rats.The optimized formulation was as follows: the content of media chain triglyceride(MCT) was 30%-34%(w/w);and the weight ratio of surfactant polyoxyl 40 hydrogenated castor oil(Cremophor RH40) and co-surfactant ethanol was 4.8-5.2.Release of QH917 from the optimized formulation was nearly unaffected by ionic strength,food,pH,rotation speed and medium volume.There was no marked difference of the absorption rate between rats with and without ligated bile duct in rat intestinal permeability technique.Inter-individual variability in absorption of the optimized formulation was negligible.Central composite design-response surface methodology is an efficient approach for optimizing formulations of self-microemulsifying drug delivery system;drug release in vitro and absorption behavior in situ of the optimized formulation is steady. |
| WOS研究方向 | Pharmacology & Pharmacy (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:2877160 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/268161]  |
| 专题 | 药物制剂研究中心 |
| 作者单位 | 1.Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. 2.School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, China.; |
| 推荐引用方式 GB/T 7714 | ZHANG Jianyuan,GAN Yong,GAN Li,et al. Optimization and evaluation of a new antischistosomal drug QH917 self-microemulsifying drug delivery system[J]. Acta Pharmaceutica Sinica,2007,42(4):434-439. |
| APA | ZHANG Jianyuan,GAN Yong,GAN Li,ZHU Chunliu,&PAN Weisan.(2007).Optimization and evaluation of a new antischistosomal drug QH917 self-microemulsifying drug delivery system.Acta Pharmaceutica Sinica,42(4),434-439. |
| MLA | ZHANG Jianyuan,et al."Optimization and evaluation of a new antischistosomal drug QH917 self-microemulsifying drug delivery system".Acta Pharmaceutica Sinica 42.4(2007):434-439. |
入库方式： OAI收割
来源：上海药物研究所
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