Properties of the Co-processed Excipient Including Microcellulose and Application in Direct Compression
文献类型：期刊论文
| 作者 | Cai Jie6; Gu Wangwen4 ; Ding Yaping5
|
| 刊名 | Chinese Journal of Pharmaceuticals
 |
| 出版日期 | 2018 |
| 卷号 | 49期号:8页码:1136-1141 |
| 关键词 | co-processing excipient direct compression piroxicam carbamazepine itraconazole content uniformity dissolution disintegration |
| ISSN号 | 1001-8255 |
| 其他题名 | 微晶纤维素共处理辅料的粉体学性质及在直接压片工艺中的应用 |
| 文献子类 | Article |
| 英文摘要 | The properties of the co-processed excipient including microcellulose,EASYtab,were investigated by evaluating fluidity,compressibility and particle size distribution of powder.The results showed that Carr index and repose angle of the co-processed excipient were 16.7% and 30.18 °,respectively.Scanning electron microscopic observation showed that the co-processed excipient was spherical,uniform and porous compared with the corresponding physical mixture containing the same composition.Piroxicam,carbamazepine and itraconazole exhibited the poor blend uniformity,low dissolution and slow disintegration,respectively.In order to investigate the improvements of the co-processed excipient in content uniformity,dissolution and disintegration of tablets prepared with direct compression process,the above three drugs were adopted as the model drugs.The quality attributes of tablets with different drug loadings were compared.As the drug loading was 20%,piroxicam tablets showed a satisfied content uniformity with the A+2.2S value of 6.53;dissolution at 60 min of carbamazepine tablets was 82.3%;itraconazole tablets could quickly disintegrate within 10 s.Compared with the corresponding physical mixture,the co-processed excipient EASYtab could significantly improve the quality attributes of tablets prepared by direct compression.Moreover,the hardness and friability of three kinds of tablets were also with the acceptable pharmacopoeial limits,even though the drug loading amount reached to 40%.These findings showed that the co-processed excipient including microcellulose reflected the excellent dilution potency in the process of direct compression. |
| WOS研究方向 | Pharmacology & Pharmacy (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:6307809 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/269157]  |
| 专题 | 药物制剂研究中心 |
| 作者单位 | 1.Shanghai Institute of Materia Medica,Chinese Academy of Sciences,; 2.; 3.Shanghai; 4.Center for Formulations System,Shanghai Institute of Materia Medica,Chinese Academy of Sciences, Shanghai 201203, China.; 5.Dept.of Chemistry,College of Sciences,Shanghai University, Shanghai 201900, China. 6.Dept.of Chemistry,College of Sciences,Shanghai University; |
| 推荐引用方式 GB/T 7714 | Cai Jie,Gu Wangwen,Ding Yaping. Properties of the Co-processed Excipient Including Microcellulose and Application in Direct Compression[J]. Chinese Journal of Pharmaceuticals,2018,49(8):1136-1141. |
| APA | Cai Jie,Gu Wangwen,&Ding Yaping.(2018).Properties of the Co-processed Excipient Including Microcellulose and Application in Direct Compression.Chinese Journal of Pharmaceuticals,49(8),1136-1141. |
| MLA | Cai Jie,et al."Properties of the Co-processed Excipient Including Microcellulose and Application in Direct Compression".Chinese Journal of Pharmaceuticals 49.8(2018):1136-1141. |
入库方式： OAI收割
来源：上海药物研究所
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