Application of Foam Aerosol in Topical Application of Skin
文献类型：期刊论文
| 作者 | SUN Di2; GUO Shiyan1,2; WANG Zhengtao2; GAN Yong1
|
| 刊名 | Chinese Journal of Pharmaceuticals
 |
| 出版日期 | 2018 |
| 卷号 | 49期号:4页码:409-416 |
| 关键词 | foam aerosol transdermal drug delivery enhanced efficacy research progress absorption mechanism |
| ISSN号 | 1001-8255 |
| 其他题名 | 泡沫型气雾剂在皮肤局部用药方面的应用 |
| 文献子类 | Article |
| 英文摘要 | As a new transdermal drug delivery system, owning to the volatilization of the propellant and volatile components of the foam aerosol, it will gradually form a saturated solution or even supersaturated solution of the drug. During this period, the drug concentration gradient and thermodynamic activity gradually increase, which prompting the rapid spread of drugs into the organization. As a result, the bioavailability of drugs increase. In addition, some excipients of foam aerosols are able to dissolve some of the intercellular lipids in the stratum corneum and destroy the stratum corneum structure, which consequently increase the drug penetration rate by reducing the resistance of the drug to penetrate. What's more, the combination of foam aerosol and microemulsion, liposomes as well as nanoparticles can greatly improve the skin permeability and enhance efficacy. Besides, due to the slight viscosity, ease of spread and no needing to exert pressure on the skin, the patients have a high compliance of foam aerosols. Through reviewing and collating recent reports on foam aerosols, the characteristics of foam aerosols, transdermal absorption mechanism, listed foam aerosol products and the latest research progress are reviewed in this paper to provide reference for the development of foam aerosol. |
| WOS研究方向 | Pharmacology & Pharmacy (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:6226287 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/269173]  |
| 专题 | 药物制剂研究中心 |
| 通讯作者 | GAN Yong |
| 作者单位 | 1.Shanghai Institute of Materia Medica, Chinese Academy of Seiences, Shanghai 201210 2.Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203; |
| 推荐引用方式 GB/T 7714 | SUN Di,GUO Shiyan,WANG Zhengtao,et al. Application of Foam Aerosol in Topical Application of Skin[J]. Chinese Journal of Pharmaceuticals,2018,49(4):409-416. |
| APA | SUN Di,GUO Shiyan,WANG Zhengtao,&GAN Yong.(2018).Application of Foam Aerosol in Topical Application of Skin.Chinese Journal of Pharmaceuticals,49(4),409-416. |
| MLA | SUN Di,et al."Application of Foam Aerosol in Topical Application of Skin".Chinese Journal of Pharmaceuticals 49.4(2018):409-416. |
入库方式： OAI收割
来源：上海药物研究所
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