Synthesis of functional phospholipids and preparation of shear-stress sensitive liposomes
文献类型：期刊论文
| 作者 | Ke Qin2; Wang Pingyuan1; Miao Yunqiu1; Liang Jinying1; He Shufang1; Zhang Xinxin1 ; Gan Yong1
|
| 刊名 | Acta Pharmaceutica Sinica
 |
| 出版日期 | 2017 |
| 卷号 | 52期号:7页码:1178-1185 |
| 关键词 | liposome thrombosis sensitivity fluorescent dye specificity |
| ISSN号 | 0513-4870 |
| 其他题名 | 功能性磷脂的合成及剪切力敏感型脂质体的制备 |
| 文献子类 | Article |
| 英文摘要 | This study aims to synthesize new phospholipids, 1,3-dipalmaminophospholipid (Pad-PC-Pad), and prepare shear-stress sensitive liposomes (SSSL). 1H NMR and MS indicated that Pad-PC-Pad were fully synthesized successfully. SSSL were prepared by filming-rehydration method with Pad-PC-Pad, which loaded calcein with aggregation-caused quenching (ACQ) characteristics to evaluate shear-stress sensitivity of liposomes and release behavior of liposomes in vitro. The results showed that the particle size of liposomes was 106.911.24 nm and liposomes had lenticular morphology under transmission electron microscope. The release of calcein was increased with ultrasonic power, which suggests that the liposomes is shear-stress sensitive. Moreover, the liposomes exhibited a releasing effect for obstructed region under high shear-stress in a model system. Therefore, we synthesized quick functional phospholipid Pad-PC-Pad and the liposomes made from Pad-PC-Pad was shear-stress sensitive, which may be used for treatment of thrombosis. |
| 资助项目 | 国家自然科学基金资助项目[00000000] ; 中国科学院青年创新促进会资助项目[00000000] |
| WOS研究方向 | Pharmacology & Pharmacy (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:6021726 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/269201]  |
| 专题 | 药物制剂研究中心 |
| 通讯作者 | Zhang Xinxin; Gan Yong |
| 作者单位 | 1.Shanghai Institute of Material Medica, Chinese Academy of Sciences, Shanghai 201203, China. 2.School of Pharmaceutical Sciences, Nanchang University, Nanchang, Jiangxi 330006, China.; |
| 推荐引用方式 GB/T 7714 | Ke Qin,Wang Pingyuan,Miao Yunqiu,et al. Synthesis of functional phospholipids and preparation of shear-stress sensitive liposomes[J]. Acta Pharmaceutica Sinica,2017,52(7):1178-1185. |
| APA | Ke Qin.,Wang Pingyuan.,Miao Yunqiu.,Liang Jinying.,He Shufang.,...&Gan Yong.(2017).Synthesis of functional phospholipids and preparation of shear-stress sensitive liposomes.Acta Pharmaceutica Sinica,52(7),1178-1185. |
| MLA | Ke Qin,et al."Synthesis of functional phospholipids and preparation of shear-stress sensitive liposomes".Acta Pharmaceutica Sinica 52.7(2017):1178-1185. |
入库方式： OAI收割
来源：上海药物研究所
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