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Preliminary study of lipid bilayer-coated calcium phosphate nanoparticles as a drug carrier for antitumor drug

文献类型：期刊论文

作者Miao Yunqiu1; He Shufang2; Liang Jinying2; Ke Qin2; Zhang Xinxin2; Wang Rui1; Gan Yong2
刊名Acta Pharmaceutica Sinica
出版日期2017
卷号52期号:6页码:977-984
关键词calcium phosphate nanoparticle paclitaxel drug release antitumor drug
ISSN号0513-4870
其他题名脂质-磷酸钙核/壳纳米粒作为抗肿瘤药物载体的初步研究
文献子类Article
英文摘要This study aims to prepare lipid bilayer-coated calcium phosphate core-shell nanoparticles (LCAPNs), which can dissolve in an acidic environment to improve the tumor cell toxicity of antitumor drug. Paclitaxel (PTX) loaded lipid coated calcium phosphate nanoparticles (PTX-LCAPNs) were prepared by thin-film dispersion method. The morphology, particle size and in vitro release behavior were characterized. Meanwhile, the intracellular uptake, intracellular dissolution, cell toxicity of PTX-LCAPNs and intracellular accumulation of PTX were evaluated in human HCC cell line (Huh-7). The results suggested that the mean diameter of the spherical LCAPNs was 124.73 6.41 nm. The PTX-LCAPNs demonstrated little drug leakage in simulated normal physiological conditions, while a rapid release was observed in simulated intracellular condition in vitro. Moreover, the PTX-LCAPNs achieved 1.7 fold improvement in the intracellular PTX concentration leading to 5-fold reduction in half maximal inhibitory concentration (IC_(50)) values of PTX compared with calcium phosphate nanoparticles loaded with PTX (PTX-CAPNs), demonstrating a stronger cancer cell lethality.
资助项目国家自然科学基金资助项目[00000000]
WOS研究方向Pharmacology & Pharmacy (provided by Clarivate Analytics)
语种中文
CSCD记录号CSCD:5998950
源URL[http://119.78.100.183/handle/2S10ELR8/269205]  
专题药物制剂研究中心
通讯作者Zhang Xinxin
作者单位1.School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.;
2.Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
推荐引用方式
GB/T 7714		 Miao Yunqiu,He Shufang,Liang Jinying,et al. Preliminary study of lipid bilayer-coated calcium phosphate nanoparticles as a drug carrier for antitumor drug[J]. Acta Pharmaceutica Sinica,2017,52(6):977-984.
APA Miao Yunqiu.,He Shufang.,Liang Jinying.,Ke Qin.,Zhang Xinxin.,...&Gan Yong.(2017).Preliminary study of lipid bilayer-coated calcium phosphate nanoparticles as a drug carrier for antitumor drug.Acta Pharmaceutica Sinica,52(6),977-984.
MLA Miao Yunqiu,et al."Preliminary study of lipid bilayer-coated calcium phosphate nanoparticles as a drug carrier for antitumor drug".Acta Pharmaceutica Sinica 52.6(2017):977-984.

入库方式： OAI收割

来源：上海药物研究所

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