Taste-masking mechanism of layer-by-layer self-assembly coating investigated by synchrotron radiation-based Fourier-transform infrared spectromicroscopy
文献类型：期刊论文
| 作者 | Feng Jing1; Guo Zhen2; Wu Li2; Yin Xianzhen2; Wang Lebing1; Yang Ming1; Zhu Weifeng1; Zhang Jiwen1
|
| 刊名 | Acta Pharmaceutica Sinica
 |
| 出版日期 | 2016 |
| 卷号 | 51期号:6页码:985-990 |
| 关键词 | taste masking anion and cation interaction film formation synchrotron radiation-based Fourier-transform infrared spectromicroscopy material distribution ibuprofen |
| ISSN号 | 0513-4870 |
| 其他题名 | 基于同步辐射红外显微成像研究层层自组装包衣矫味机制 |
| 文献子类 | Article |
| 英文摘要 | Ibuprofen lipid pellets prepared by melting method could mask the bitter taste of the drug to some extent. The pellets were further coated with chitosan (cationic) and gelatin (anionic) by ionic interaction layer-by-layer self-assembly (LBL) coating to improve masking effects. In this paper, the release percentage of drugs in short time (1 min) was utilized as an indicator for the taste-masking, and it had confirmed the LBL coating inhibited the release of model drug of ibuprofen. Synchrotron radiation-based Fourier-transform infrared spectromicroscopy (SR-FTIR) has been applied to investigate the material distributions on the cross section of pellets and film. Characteristic absorptions of the compositions were obtained by SR-FTIR single spectrum scanning. The distributions of the drug and materials in coated films were determined by SR-FTIR mapping. The FTIR absorptions of chitosan and gelatin on the surface of lipid pellets was examined to verify the existence of chitosan and gelatin on the surface and a film formed using SR-FTIR ratio analysis. Whilst pellets coated only by chitosan or gelatin did not show the typical absorption of chitosan or gelatin, which confirmed the effects of ionic interaction on the film forming process. In conclusion, the method of SR-FTIR established for the study of the existence and distribution of materials in coated film offers a new choice for researches on membranes/films in drug delivery systems and pharmaceutical preparations. |
| 资助项目 | 国家自然科学基金资助项目[00000000] ; 国家科技重大专项[00000000] |
| WOS研究方向 | Pharmacology & Pharmacy (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:5730629 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/269251]  |
| 专题 | 药物制剂研究中心 分子影像中心（筹） |
| 通讯作者 | Zhang Jiwen |
| 作者单位 | 1.Jiangxi University of Chinese Medicine, Nanchang, Jiangxi 330004, China.; 2.Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201210, China. |
| 推荐引用方式 GB/T 7714 | Feng Jing,Guo Zhen,Wu Li,et al. Taste-masking mechanism of layer-by-layer self-assembly coating investigated by synchrotron radiation-based Fourier-transform infrared spectromicroscopy[J]. Acta Pharmaceutica Sinica,2016,51(6):985-990. |
| APA | Feng Jing.,Guo Zhen.,Wu Li.,Yin Xianzhen.,Wang Lebing.,...&Zhang Jiwen.(2016).Taste-masking mechanism of layer-by-layer self-assembly coating investigated by synchrotron radiation-based Fourier-transform infrared spectromicroscopy.Acta Pharmaceutica Sinica,51(6),985-990. |
| MLA | Feng Jing,et al."Taste-masking mechanism of layer-by-layer self-assembly coating investigated by synchrotron radiation-based Fourier-transform infrared spectromicroscopy".Acta Pharmaceutica Sinica 51.6(2016):985-990. |
入库方式： OAI收割
来源：上海药物研究所
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