Formation mechanism of Pickering emulsions induced by self-assembly of medium chain triglycerides and alpha-cyclodextrin
文献类型：期刊论文
| 作者 | Liu Mingqun2; Wu Li1; Li Haiyan1 ; Yin Xianzhen1; Hu Xiongwei1; Gui Shuangying2; Zhang Jiwen2
|
| 刊名 | Acta Pharmaceutica Sinica
 |
| 出版日期 | 2016 |
| 卷号 | 51期号:3页码:469-474 |
| 关键词 | cyclodextrin medium chain triglyceride self-assembly supramolecule Pickering emulsion formation mechanism |
| ISSN号 | 0513-4870 |
| 其他题名 | 中链甘油三酯/alpha-环糊精分子自组装介导的Pickering乳的形成机制 |
| 文献子类 | Article |
| 英文摘要 | In this study, the Pickering emulsions were prepared using medium chain triglycerides (MCT) and alpha-cyclodextrin (alpha-CD) and the formation mechanism was studied by means of several physicochemical techniques. The MCT/alpha-CD microparticles, which stabilized the emulsions, were characterized by the measurement of interfacial tension and the contact angle (theta_(ow)), powder X ray diffraction (XRD), scanning electron microscope (SEM), high performance liquid chromatography (HPLC), differential interference microscope (DIM), Cryo-scanning electron microscopy (Cryo-SEM). The physical stability of emulsions with different alpha-CD content in the continuous aqueous phase was investigated by determination of the droplet size and sedimentation rate, combined with the observation of droplet morphologies by the inverted phase contrast microscope. As a result, it was observed that the amphiphilic supramolecule of MCT and alpha-CD were indeed formed. Furthermore, MCT/alpha-CD microparticles formed by the aggregation of MCT/alpha-CD supramolecule absorbed at the oil/water interface, and then forming a membrane structure to stabilize emulsion. In addition, the average theta_(ow) for the MCT/alpha-CD microparticles was (46.1 3.4)° which stabilized O/W emulsion. When the content of alpha-CD was increased in the continuous phase, there were more microparticles formed at the oil/water interface and in the continuous aqueous phase, which resulted in smaller particle size of droplet and higher viscosity of the continuous phase. In summary, the study suggest that alpha-CD/MCT/water emulsions were of O/W Pickering emulsions and the physical stability was better for emulsions with higher content of alpha-CD in the continuous phase. |
| 资助项目 | 国家自然科学基金资助项目[00000000] |
| WOS研究方向 | Pharmacology & Pharmacy (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:5650577 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/269256]  |
| 专题 | 药物制剂研究中心 分子影像中心（筹） |
| 通讯作者 | Zhang Jiwen |
| 作者单位 | 1.Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201210, China. 2.School of Pharmacy, Anhui University of Chinese Medicine, Hefei, Anhui 230012, China.; |
| 推荐引用方式 GB/T 7714 | Liu Mingqun,Wu Li,Li Haiyan,et al. Formation mechanism of Pickering emulsions induced by self-assembly of medium chain triglycerides and alpha-cyclodextrin[J]. Acta Pharmaceutica Sinica,2016,51(3):469-474. |
| APA | Liu Mingqun.,Wu Li.,Li Haiyan.,Yin Xianzhen.,Hu Xiongwei.,...&Zhang Jiwen.(2016).Formation mechanism of Pickering emulsions induced by self-assembly of medium chain triglycerides and alpha-cyclodextrin.Acta Pharmaceutica Sinica,51(3),469-474. |
| MLA | Liu Mingqun,et al."Formation mechanism of Pickering emulsions induced by self-assembly of medium chain triglycerides and alpha-cyclodextrin".Acta Pharmaceutica Sinica 51.3(2016):469-474. |
入库方式： OAI收割
来源：上海药物研究所
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