Preparation and Pharmacokinetics in Rats of Topotecan Hydrochloride Liposomes by Ammonium Sulfate Gradient Method
文献类型：期刊论文
| 作者 | Xu Leilei3; Chen Xianzhi2; Li Yaping3 ; Gu Wangwen1
|
| 刊名 | Chinese Journal of Pharmaceuticals
 |
| 出版日期 | 2014 |
| 卷号 | 45期号:12页码:1139-1142 |
| 关键词 | ammonium sulfate gradient method topotecan hydrochloride liposome pharmacokinetics in vitro release |
| ISSN号 | 1001-8255 |
| 其他题名 | 硫酸铵梯度法制备盐酸拓扑替康脂质体及其在大鼠体内的药动学 |
| 文献子类 | Article |
| 英文摘要 | The topotecan hydrochloride liposomes modified with distearoyl phosphatidyl ethanolamine-polyethylene glycol (DSPE-PEG) were prepared by ammonium sulfate gradient method with hydrogenated phospholipids and cholesterol as lipid materials. The effects of formulation factors on encapsulation efficiency of the product were investigated by single factor tests. The differences of in vitro release and in vivo pharmacokinetics in rats between the optimal product and common injection were compared. The results showed that the encapsulation efficiency of the optimal product was (93.141.52)% with the mean particle size of 69.6 nm. The drug could completely release within 144 h in the medium containing 10% fetal bovine serum. Furthermore, the AUC_(0t) of the liposomes group was 61 times higher than that of the injection group. |
| WOS研究方向 | Pharmacology & Pharmacy (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:5313625 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/269303]  |
| 专题 | 药物制剂研究中心 |
| 作者单位 | 1.Center for Formulations System, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. 2.Shenyang Pharmaceutical University, Shenyang, Liaoning 117000, China.; 3.School of Pharmacy, Jiangsu University, Zhenjiang, Jiangsu 212013, China.; |
| 推荐引用方式 GB/T 7714 | Xu Leilei,Chen Xianzhi,Li Yaping,et al. Preparation and Pharmacokinetics in Rats of Topotecan Hydrochloride Liposomes by Ammonium Sulfate Gradient Method[J]. Chinese Journal of Pharmaceuticals,2014,45(12):1139-1142. |
| APA | Xu Leilei,Chen Xianzhi,Li Yaping,&Gu Wangwen.(2014).Preparation and Pharmacokinetics in Rats of Topotecan Hydrochloride Liposomes by Ammonium Sulfate Gradient Method.Chinese Journal of Pharmaceuticals,45(12),1139-1142. |
| MLA | Xu Leilei,et al."Preparation and Pharmacokinetics in Rats of Topotecan Hydrochloride Liposomes by Ammonium Sulfate Gradient Method".Chinese Journal of Pharmaceuticals 45.12(2014):1139-1142. |
入库方式： OAI收割
来源：上海药物研究所
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