Poloxamer188-PLGA Nanodrug Delivery System for Overcoming Drug Resistant Tumor
文献类型：期刊论文
| 作者 | Wang Huixin1; Wang Huiyuan2 ; Zhang Meng2; Tan Jiao2; Wang Yaping2; Liang Jianming2; Zhao Yongxing1; Huang Yongzhuo2
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| 刊名 | Chinese Journal of Modern Applied Pharmacy
 |
| 出版日期 | 2014 |
| 卷号 | 31期号:10页码:1167-1170 |
| 关键词 | MCF-7/ADR drug resistance PLGA nanoparticles Poloxamer doxorubicin MCF-7/ADR |
| ISSN号 | 1007-7693 |
| 其他题名 | 泊洛沙姆188-PLGA 纳米给药系统对抗耐药肿瘤的研究 |
| 文献子类 | Article |
| 英文摘要 | OBJECTIVE To improve the treatment efficacy of doxorubicin to human breast cancer drug-resistant MCF-7/ADR cells, the synthesis of Poloxamer 188-PLGA conjugates and preparation of doxorubicin-loaded Poloxamer188 modified PLGA nanoparticles were investiagated. METHODS Poloxamer 188-PLGA was synthesized by using EDC/NHS, and the product was confirmed by nuclear magnetic resonance(NMR) and its critical micelle concentration was measured. Doxorubicin-loaded nanoparticles were prepared by the nanoprecipitation method, and the particle size was analyzed by laser scattering particle counter. Cellular uptake was observed using a fluorescence microscope and cell viability was determined by MTT assay. RESULTS Poloxamer 188-PLGA was synthesized successfully, and the average size of doxorubicin-loaded nanoparticles was about 140 nm. The nanoparticles could improve the intracellular delivery of doxorubicin and thus enhance the cytotoxicity in MCF-7/ADR cells. CONCLUSION Poloxamer 188 modified PLGA nanoparticles can reverse drug resistance and increase the cytotoxicity of doxorubicin in MCF-7/ADR cells. |
| 资助项目 | 国家自然科学基金[00000000] ; 中国博士后自然科学基金[00000000] |
| WOS研究方向 | Pharmacology & Pharmacy (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:5311597 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/269304]  |
| 专题 | 药物制剂研究中心 |
| 通讯作者 | Huang Yongzhuo |
| 作者单位 | 1.School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, Henan 450001, China.; 2.Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. |
| 推荐引用方式 GB/T 7714 | Wang Huixin,Wang Huiyuan,Zhang Meng,et al. Poloxamer188-PLGA Nanodrug Delivery System for Overcoming Drug Resistant Tumor[J]. Chinese Journal of Modern Applied Pharmacy,2014,31(10):1167-1170. |
| APA | Wang Huixin.,Wang Huiyuan.,Zhang Meng.,Tan Jiao.,Wang Yaping.,...&Huang Yongzhuo.(2014).Poloxamer188-PLGA Nanodrug Delivery System for Overcoming Drug Resistant Tumor.Chinese Journal of Modern Applied Pharmacy,31(10),1167-1170. |
| MLA | Wang Huixin,et al."Poloxamer188-PLGA Nanodrug Delivery System for Overcoming Drug Resistant Tumor".Chinese Journal of Modern Applied Pharmacy 31.10(2014):1167-1170. |
入库方式： OAI收割
来源：上海药物研究所
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