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Preparation and in vitro evaluation of tranexamic acid nano - cream for transdermal delivery

文献类型：期刊论文

作者Li Meiyun1; Liu Jinfen1; Zhao Yanan2; Chen Xi2; Gan Yong2; Guo Shiyan2; Li Daning1
刊名Chinese Journal of New Drugs and Clinical Remedies
出版日期2014
卷号33期号:9页码:683-688
关键词tranexamic acid nanostructures administration, cutaneous transdermal effect nano - cream
ISSN号1007-7669
其他题名氨甲环酸纳米乳膏的制备及体外透皮效果评价
文献子类Article
英文摘要AIM To prepare tranexamic acid nano-cream (TA-NC) and evaluate the transdermal effect of TA-NC in vitro. METHODS TA-NC was prepared by further process from TA nano - emulsion which was got through high pressure homogenizing method. TA - NC was characterized for the particle size,morphology and encapsulation efficiency. The transdermal effect of the nano-cream was evaluated by in vitro transdermal delivery/ permeation experiments by using skin of nude mice as model. And the TA - NC labeled with Nile red was prepared to study the improved absorption behavior into the dermis of TA by confocal assay in skin of nude mice,too. Accelerated stability test was also carried out for 6 months. RESULTS The prepared TA - NC was (109.9 7.4) nm and presented a regular spherical surface with homogeneous distribution. The encapsulation efficiency was (90.13 2.90) %. In vitro transdermal absorption experiment showed that the retention of TA in skin was saturated after 6 h administration in the TA - NC group,and the total permeated amount of TA was (163.9 7.4) mug · cm~(-2), whereas the amount of TA solution group was ( 15.9 0.8) mug · cm~(-2), with a significant difference (P < 0.01) . Comparing with Nile red - TA solution which observed fluorescent only in cuticle, the Nile red labeled TA-NC was observed to permeate the cuticle and epidermis and reach the dermis by confocal assay,and the smaller the particle size of TA-NC, the stronger the ability of transdermal ability. The samples showed no significant differences in external properties, related substance, contents and particle size after accelerated stability test. CONCLUSION The TA-NC preparation technology is simple, and the TANC is good stability and can improve the transdermal absorption of TA significantly.
资助项目上海市卫生局青年科研项目[00000000] ; 中国科学院上海药物研究所临床研究中心科研项目[00000000]
WOS研究方向Pharmacology & Pharmacy (provided by Clarivate Analytics)
语种中文
CSCD记录号CSCD:5250551
源URL[http://119.78.100.183/handle/2S10ELR8/269313]  
专题药物制剂研究中心
作者单位1.Department of Dermatology, Central Hospital of Shanghai Xuhui District, SHANGHAI 200031, China.;
2.Center for Drug Delivery System, Shanghai Institute of Materia Medica Chinese Academy of Sciences, SHANGHAI 201203, China.
推荐引用方式
GB/T 7714		 Li Meiyun,Liu Jinfen,Zhao Yanan,et al. Preparation and in vitro evaluation of tranexamic acid nano - cream for transdermal delivery[J]. Chinese Journal of New Drugs and Clinical Remedies,2014,33(9):683-688.
APA Li Meiyun.,Liu Jinfen.,Zhao Yanan.,Chen Xi.,Gan Yong.,...&Li Daning.(2014).Preparation and in vitro evaluation of tranexamic acid nano - cream for transdermal delivery.Chinese Journal of New Drugs and Clinical Remedies,33(9),683-688.
MLA Li Meiyun,et al."Preparation and in vitro evaluation of tranexamic acid nano - cream for transdermal delivery".Chinese Journal of New Drugs and Clinical Remedies 33.9(2014):683-688.

入库方式： OAI收割

来源：上海药物研究所

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