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Antitumor efficacy of irinotecan-loaded galactosyl modified lipid bilayer-coated mesoporous silica nanoparticles against hepatocellular carcinoma cells

文献类型：期刊论文

作者Chen Xi2; Zhang Xinxin1; Li Feifei1; Zhao Yanan2; Jia Zheng3; Gan Yong1; Li Juan2
刊名Acta Pharmaceutica Sinica
出版日期2014
卷号49期号:5页码:718-725
关键词mesoporous silica hepatocellular carcinoma galactose nanoparticle irinotecan
ISSN号0513-4870
其他题名载盐酸伊立替康的半乳糖修饰脂质-介孔硅核壳纳米粒对肝癌细胞的抑制效果
文献子类Article
英文摘要The purpose of this study is to prepare galactosyl modified lipid bilayer-coated mesoporous silica nanoparticles (GPEM) to enhance the antitumor efficacy against hepatocellular carcinoma cells. The irinotecan (CPT-11) loaded mesoporous silica nanoparticles (MSNs) was coated with the Gal-P123 modified functional lipid bilayer by thin-film dispersion method. Nanoparticles were characterized with particle size, zeta potential, morphology and drug release in vitro. Afterwards, the cell uptake, intracellular concentration of CPT-11, cell apoptosis rate and cytotoxicity were evaluated on human hepatocellular carcinoma cell line Huh-7. The results showed that MSNs were coated with intact lipid bilayers and the nanoparticles had clear core-shell structure. GPEM is stable with the mean particle size of (78.01 2.04) nm. The low leakage rate in normal physiological conditions in vitro is contributed to the protection of stable lipid bilayer, and the fast drug release in acid environment due to the destruction of the lipid bilayer. On the cell level, the vector could improve the intracellular CPT-11 concentration by 4 times because of the functional lipid bilayer. The high CPT-11 concentration led to the increasement of apoptosis rate by 48.6%, and the reduction of half maximal inhibitory concentration (IC_(50)) values of CPT-11 by 2 times, indicating stronger cell cytotoxicity.
资助项目河北省自然科学基金资助项目[00000000] ; "十二五"重大专项创制项目[00000000]
WOS研究方向Pharmacology & Pharmacy (provided by Clarivate Analytics)
语种中文
CSCD记录号CSCD:5130410
源URL[http://119.78.100.183/handle/2S10ELR8/269340]  
专题药物制剂研究中心
作者单位1.Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.;
2.China Pharmaceutical University, Nanjing, Jiangsu 210009, China.;
3.Tangshan Vocational and Technical College, Tangshan, Hebei 063004, China.
推荐引用方式
GB/T 7714		 Chen Xi,Zhang Xinxin,Li Feifei,et al. Antitumor efficacy of irinotecan-loaded galactosyl modified lipid bilayer-coated mesoporous silica nanoparticles against hepatocellular carcinoma cells[J]. Acta Pharmaceutica Sinica,2014,49(5):718-725.
APA Chen Xi.,Zhang Xinxin.,Li Feifei.,Zhao Yanan.,Jia Zheng.,...&Li Juan.(2014).Antitumor efficacy of irinotecan-loaded galactosyl modified lipid bilayer-coated mesoporous silica nanoparticles against hepatocellular carcinoma cells.Acta Pharmaceutica Sinica,49(5),718-725.
MLA Chen Xi,et al."Antitumor efficacy of irinotecan-loaded galactosyl modified lipid bilayer-coated mesoporous silica nanoparticles against hepatocellular carcinoma cells".Acta Pharmaceutica Sinica 49.5(2014):718-725.

入库方式： OAI收割

来源：上海药物研究所

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